Kechagias Nikos, Ntomouchtsis Aris, Patrikidou Anna, Christoforidou Barbara, Andreadis Charalambos, Vahtsevanos Konstantinos
Department of Oral and Maxillofacial Surgery, Theagenion Cancer Hospital of Thessaloniki, Davaki 18, 572 00 Lagadas, Thessaloniki, Greece.
Oral Maxillofac Surg. 2012 Dec;16(4):377-81. doi: 10.1007/s10006-011-0300-y. Epub 2011 Nov 15.
We present a metastatic tumour from the breast to the gingiva, with the rare finding of tooth invasion. Metastatic tumours to the oral region are uncommon. The breast is the most common primary site for metastatic tumours to the jawbones in women, with the mandible being most often affected.
We report the case of a 52-year-old Caucasian woman who presented with a swelling of the buccal mucosa in the molar region of the left mandible. Biopsy revealed a metastatic lesion, with involvement of the two adjacent molars. Immunohistochemical analysis ruled out other malignancies and confirmed the diagnosis of a ductal breast carcinoma origin.
Management in such cases should be in the context of the treatment of a metastatic disease that could prolong survival and improve quality of life, but is not curative. Tooth invasion has been described since 1910 for different primary malignancies with distant metastases to the oral cavity. This report seems to describe the second case in the literature of a metastatic breast carcinoma to the mandible with tooth invasion. Management in such cases should be in the context of the treatment of a metastatic disease that could prolong survival and improve quality of life, but is not curative.
我们报告一例乳腺转移至牙龈的肿瘤，伴有罕见的牙齿侵犯情况。口腔区域的转移瘤并不常见。在女性中，乳腺是转移至颌骨的肿瘤最常见的原发部位，下颌骨最常受累。
我们报告一名52岁白种女性病例，该患者左侧下颌磨牙区颊黏膜肿胀。活检显示为转移瘤，累及相邻的两颗磨牙。免疫组化分析排除了其他恶性肿瘤，确诊为乳腺导管癌转移。
此类病例的治疗应基于转移性疾病的治疗方案，其目的是延长生存期和改善生活质量，但无法治愈。自1910年以来，已有不同原发恶性肿瘤远处转移至口腔并侵犯牙齿的相关描述。本报告似乎是文献中第二例乳腺转移癌侵犯下颌骨并累及牙齿的病例。此类病例的治疗应基于转移性疾病的治疗方案，其目的是延长生存期和改善生活质量，但无法治愈。
