Nakajima Masanobu, Kato Hiroyuki, Miyazaki Tatsuya, Fukuchi Minoru, Masuda Norihiro, Fukai Yasuyuki, Sohda Makoto, Inose Takanori, Sakai Makoto, Sano Akihiko, Tanaka Naritaka, Ahmad Faried, Kuwano Hiroyuki
Department of General Surgical Science, Gunma University, Gunma, Japan.
Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1555-60. doi: 10.5754/hge09758.
BACKGROUND/AIMS: Heat shock proteins (HSPs) are well known as tumor rejection antigens, most notable of which is HSP70. HSP110 is classified as a member of the HSP70/DnaK superfamily. The objective of this study was to clarify the clinicopathological and prognostic significance of Heat Shock Protein 110 expression and T lymphocyte infiltration in esophageal cancer.
Immunohistochemical staining of HSP110, CD4 and CD8 were performed on surgical specimens obtained from 124 patients with esophageal cancer.
The expression of HSP110 correlated inversely with depth of invasion (p<0.0001), lymph node metastasis (p=0.0163), pathological stage (p<0.0001), lymphatic invasion (p=0.0104), blood vessel invasion (p=0.0027), infiltrative growth pattern (p=0.0368) and correlated positively with CD4+ T lymphocyte infiltration (p=0.0018). Reduction of HSP110 expression was significantly correlated with poor prognosis (p=0.0010).
The present findings suggest that HSP110 expression and T lymphocyte infiltration is a significant prognostic factor for esophageal cancer.
背景/目的：热休克蛋白（HSPs）作为肿瘤排斥抗原广为人知，其中最显著的是HSP70。HSP110被归类为HSP70/DnaK超家族的成员。本研究的目的是阐明热休克蛋白110表达和T淋巴细胞浸润在食管癌中的临床病理及预后意义。
对124例食管癌患者手术标本进行HSP110、CD4和CD8免疫组化染色。
HSP110的表达与浸润深度呈负相关（p<0.0001），与淋巴结转移呈负相关（p=0.0163），与病理分期呈负相关（p<0.0001），与淋巴浸润呈负相关（p=0.0104），与血管浸润呈负相关（p=0.0027），与浸润性生长模式呈负相关（p=0.0368），与CD4+T淋巴细胞浸润呈正相关（p=0.0018）。HSP110表达降低与预后不良显著相关（p=0.0010）。
目前的研究结果表明，HSP110表达和T淋巴细胞浸润是食管癌的重要预后因素。
