Rheumatology Unit, Evangelical University Hospital of Curitiba, Rua João Azolin, 660, CEP 82015-040, Curitiba, Paraná, Brazil.
Clin Rheumatol. 2012 Mar;31(3):553-6. doi: 10.1007/s10067-011-1889-9. Epub 2011 Nov 18.
Antinucleosome antibodies have been found with variable prevalence in systemic lupus erythematosus (SLE) and were associated with more severe disease. This research aims to study the prevalence of antinucleosome antibodies in a sample of Brazilian adult SLE patients and their association with clinical findings and disease activity. Ninety-two adult patients (81 females and 11 males, with mean age of 37.29 ± 10.98 years) with SLE were studied for clinical and antibody profile, disease activity by SLE disease activity index (SLEDAI), and presence of antinucleosome antibodies by ELISA. The prevalence of antinucleosome antibodies was 61.9% (mean titer, 87.8 ± 62.6 U). No relationship was found of antinucleosome presence and any of the studied clinical features. A positive association was detected with anti-DNA (p = 0.001) and SLEDAI (p < 0.0001), but not with anti-Sm, anti-Ro, anti-La, and anti-RNP. No specific disease feature could be associated with the presence of antinucleosome; however, a positive relationship was detected with disease activity measured by SLEDAI and with anti-DNA presence.
抗核小体抗体在系统性红斑狼疮（SLE）中具有不同的患病率，且与更严重的疾病相关。本研究旨在研究巴西成人 SLE 患者样本中抗核小体抗体的患病率及其与临床发现和疾病活动的关系。对 92 名成年 SLE 患者（81 名女性和 11 名男性，平均年龄 37.29±10.98 岁）进行了临床和抗体特征、SLE 疾病活动指数（SLEDAI）评估的疾病活动以及 ELISA 检测抗核小体抗体的研究。抗核小体抗体的患病率为 61.9%（平均滴度，87.8±62.6 U）。未发现抗核小体的存在与任何研究的临床特征有关。与抗 DNA（p=0.001）和 SLEDAI（p<0.0001）呈正相关，但与抗 Sm、抗 Ro、抗 La 和抗 RNP 无关。无法将任何特定的疾病特征与核小体的存在联系起来，但与 SLEDAI 评估的疾病活动和抗 DNA 存在呈正相关。
