Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5 ga, Seongbuk-gu, Seoul, 136-705, Korea.
Inflamm Res. 2012 Feb;61(2):143-9. doi: 10.1007/s00011-011-0398-2. Epub 2011 Nov 17.
The aim of this study was to determine whether interleukin-23R (IL-23R) polymorphisms confer susceptibility to ankylosing spondylitis (AS).
The authors conducted meta-analyses on associations between IL-23R polymorphisms and AS susceptibility, using fixed and random effects models.
A total of 10 studies (14 separate comparisons) were included in this meta-analysis, which included European and Asian populations. Meta-analysis revealed a significant association between AS and the two alleles of rs11209032 polymorphism in all study subjects (OR = 1.182, 95% CI 1.120-1.249, P = 0.000). Stratification by ethnicity identified a significant association between this polymorphism and AS in the European (OR = 1.234, 95% CI 1.159-1.313, P = 0.000), but not in the Asian populations (OR = 1.030, 95% CI 0.921-1.152, P = 0.608). Meta-analyses of rs1004819, rs10489629, rs1343151, rs1495965, and rs2201841 polymorphisms showed the same pattern as that shown by rs11209032 meta-analysis. Meta-analysis also revealed a significant association between the two alleles of the rs11209026 and the rs11465804 polymorphisms and the risk of developing AS in Europeans. Interestingly, the rs7517847 polymorphism was found to be significantly associated with AS susceptibility in both Europeans and Asians.
This meta-analysis shows that the IL-23R polymorphisms are associated with the development of AS in Europeans.
本研究旨在确定白细胞介素-23 受体（IL-23R）多态性是否与强直性脊柱炎（AS）易感性相关。
作者采用固定效应模型和随机效应模型对 IL-23R 多态性与 AS 易感性的关联进行了荟萃分析。
本荟萃分析共纳入 10 项研究（14 项独立比较），包括欧洲和亚洲人群。荟萃分析显示，所有研究对象中，rs11209032 多态性的两个等位基因与 AS 显著相关（OR=1.182，95%CI 1.120-1.249，P=0.000）。按种族分层，该多态性与欧洲人群的 AS 显著相关（OR=1.234，95%CI 1.159-1.313，P=0.000），但与亚洲人群无关（OR=1.030，95%CI 0.921-1.152，P=0.608）。rs1004819、rs10489629、rs1343151、rs1495965 和 rs2201841 多态性的荟萃分析结果与 rs11209032 多态性的荟萃分析结果一致。荟萃分析还显示，rs11209026 和 rs11465804 多态性的两个等位基因与欧洲人群 AS 的发病风险显著相关。有趣的是，rs7517847 多态性在欧洲人和亚洲人中均与 AS 易感性显著相关。
本荟萃分析表明，IL-23R 多态性与欧洲人群 AS 的发生有关。
