Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032 Hefei, Anhui, China.
Rheumatol Int. 2012 May;32(5):1209-14. doi: 10.1007/s00296-010-1769-7. Epub 2011 Jan 21.
Up to now, many publications have evaluated the correlation between IL-23R polymorphisms and ankylosing spondylitis with conflicting results. We perform this meta-analysis to collect all the relevant studies up to date to further clarify the association of IL-23R polymorphisms with AS. Relevant published data were retrieved through Medline, PubMed, Embase, Web of Science, CNKI, Chinese BioMedical Literature Database on disc, and the statistical analysis was conducted using Stata 11.0. (1) A total of 11 literatures, including 13 population samples, were studied. (2) The allele A frequency of rs11209032 was higher in the AS group than in the controls (A vs. G: OR = 1.173, 95% CI = 1.107-1.243, P < 0.001). (3) The allele A of rs1004819 was higher in the AS group than in the controls in both all-pooled population (A vs. G: OR = 1.147, 95% CI = 1.022-1.287, P = 0.02) and Europe-pooled population (A vs. G: OR = 1.199, 95% CI = 1.007-1.429, P = 0.042). (4) The allele frequency T of rs1343151, G of rs10489629, and A of rs11209026 was lower in the AS group than in the controls. (5) No significant differences were found in allele frequency of rs10889677 polymorphism between cases and controls by random effects model. We concluded that the genetic susceptibility for AS is associated with the IL-23R gene polymorphisms. The protective SNPs include rs1343151, rs10489629, and rs11209026 while rs1004819 and rs11209032 may be the susceptibility SNPs.
迄今为止，许多出版物已经评估了 IL-23R 多态性与强直性脊柱炎之间的相关性，但结果存在冲突。我们进行了这项荟萃分析，以收集迄今为止所有相关研究，以进一步阐明 IL-23R 多态性与 AS 的相关性。通过 Medline、PubMed、Embase、Web of Science、CNKI、中国生物医学文献光盘数据库检索相关发表数据，并使用 Stata 11.0 进行统计分析。（1）共研究了 11 篇文献，包括 13 个人群样本。（2）rs11209032 的等位基因 A 在 AS 组中的频率高于对照组（A 对 G：OR = 1.173，95%CI = 1.107-1.243，P < 0.001）。（3）在所有人群中，rs1004819 的等位基因 A 在 AS 组中的频率高于对照组（A 对 G：OR = 1.147，95%CI = 1.022-1.287，P = 0.02）和欧洲人群（A 对 G：OR = 1.199，95%CI = 1.007-1.429，P = 0.042）。（4）rs1343151 的等位基因 T、rs10489629 的等位基因 G 和 rs11209026 的等位基因 A 在 AS 组中的频率低于对照组。（5）采用随机效应模型，rs10889677 多态性的等位基因频率在病例组和对照组之间无显著差异。我们得出结论，AS 的遗传易感性与 IL-23R 基因多态性有关。保护 SNP 包括 rs1343151、rs10489629 和 rs11209026，而 rs1004819 和 rs11209032 可能是易感 SNP。
