Department of Humanities and management, Wannan Medical College, Wuhu, China.
Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Postgrad Med J. 2018 Sep;94(1115):508-516. doi: 10.1136/postgradmedj-2018-135665. Epub 2018 Oct 15.
The aim of this study was to perform a meta-analysis to derive precise estimation of the association of interleukin-23 receptor (IL-23R), IL-1 receptor 2 (IL-1R2), IL-12 beta (IL-12B), IL-10 and tumour necrosis factor (TNF)-α polymorphisms with ankylosing spondylitis (AS) susceptibility.
A systematic literature search was conducted to identify the relevant studies. Pooled OR with 95% CI was calculated to assess the strength of the association in a fixed or random-effects model.
A total of 13 917 cases and 19 849 controls in 43 eligible studies were included in the meta-analysis. Seventeen single-nucleotide polymorphisms (SNPs) in the abovementioned five cytokine genes were evaluated. The results indicate that the nine SNPs (rs11209026, rs1004819, rs10489629, rs11465804, rs1343151, rs11209032, rs1495965, rs7517847, rs2201841) of IL-23R are associated with AS susceptibility in all study subjects in the allelic model. Moreover, stratification by ethnicity identified a significant association between seven SNPs of IL-23R and AS susceptibility in Europeans and Americans, but not in Asians. In addition, the IL-10-819 C/T and TNF-α-857 C/T polymorphisms also confer susceptibility to AS, especially in Asian population.
The results suggested that the genetic susceptibility for AS is associated with the nine SNPs of IL-23R in overall population. In the subgroup analysis, significant associations were shown in European and American population, but not in Asian population. Our results also suggest that IL-10-819 C/T and TNF-α-857 C/T polymorphism might be associated with AS risk, especially in Asian population.
本研究旨在进行荟萃分析，以得出白细胞介素-23 受体（IL-23R）、白细胞介素-1 受体 2（IL-1R2）、白细胞介素-12β（IL-12B）、白细胞介素-10 和肿瘤坏死因子（TNF）-α 多态性与强直性脊柱炎（AS）易感性关联的精确估计。
系统地进行文献检索以确定相关研究。采用固定或随机效应模型计算合并比值比（OR）和 95%置信区间（CI）以评估关联强度。
共有 43 项符合条件的研究纳入了 13917 例病例和 19849 例对照。对上述五个细胞因子基因中的 17 个单核苷酸多态性（SNP）进行了评估。结果表明，IL-23R 的 9 个 SNP（rs11209026、rs1004819、rs10489629、rs11465804、rs1343151、rs11209032、rs1495965、rs7517847、rs2201841）在所有研究对象的等位基因模型中与 AS 易感性相关。此外，按种族进行分层发现，IL-23R 的 7 个 SNP 与欧洲人和美国人的 AS 易感性之间存在显著关联，但在亚洲人中不存在。此外，IL-10-819 C/T 和 TNF-α-857 C/T 多态性也与 AS 易感性相关，尤其是在亚洲人群中。
结果表明，AS 的遗传易感性与总体人群中 IL-23R 的 9 个 SNP 相关。在亚组分析中，在欧洲人和美国人中显示出显著关联，但在亚洲人中没有。我们的结果还表明，IL-10-819 C/T 和 TNF-α-857 C/T 多态性可能与 AS 风险相关，尤其是在亚洲人群中。
