Scott D W, Miller W H
Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Cornell Vet. 1990 Oct;80(4):381-7.
Forty-three dogs having pruritus associated with atopy, flea bite hypersensitivity, and idiopathy were randomly assigned to 1 of 2 treatment protocols. Twenty-three dogs received chlorpheniramine in combination with a fatty acid supplement (DVM Derm Caps). Twenty dogs received the fatty acid supplement at twice the manufacturer's recommended dosage. All 43 dogs were known to be unresponsive to chlorpheniramine and the manufacturer's recommended dosage of the fatty acid supplement when either drug was used alone. Pruritus was satisfactorily controlled in 34.8% of the dogs in the chlorpheniramine--DVM Derm Caps protocol. No dog in the double DVM Derm Caps protocol showed a beneficial response. Side effects were uncommon and mild with either protocol.
43只患有与特应性、跳蚤叮咬过敏和不明原因相关瘙痒的犬被随机分配到2种治疗方案中的1种。23只犬接受氯苯那敏与脂肪酸补充剂（DVM Derm Caps）联合治疗。20只犬接受两倍于制造商推荐剂量的脂肪酸补充剂。已知所有43只犬在单独使用氯苯那敏或制造商推荐剂量的脂肪酸补充剂时均无反应。在氯苯那敏-DVM Derm Caps治疗方案中，34.8%的犬瘙痒得到了满意控制。双倍DVM Derm Caps治疗方案中没有犬表现出有益反应。两种治疗方案的副作用均不常见且轻微。
