Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
Curr Allergy Asthma Rep. 2012 Feb;12(1):55-63. doi: 10.1007/s11882-011-0232-5.
The apparent increase in food allergy prevalence has led to a surge in the amount of clinical and basic science research dedicated to the field. At the current time, allergen avoidance remains the cornerstone of treatment; however, recent clinical trials investigating various forms of immunotherapy have opened doors to the possible future application of an active treatment strategy in everyday practice. In addition, improvements in molecular biology have allowed researchers to purify, clone, and modify allergens, thus laying the groundwork for research on vaccines using modified proteins of decreased allergenicity. Finally, various allergen-nonspecific immunomodulatory therapies are also being investigated as a means to alter the immune response to food allergens. With these emerging therapeutic strategies, it is hoped that practitioners will have options in caring for their food-allergic patients in the near future.
食物过敏患病率的明显增加促使大量临床和基础科学研究投入该领域。目前，避免过敏原仍然是治疗的基石；然而，最近针对各种形式免疫疗法的临床试验为在日常实践中应用主动治疗策略开辟了道路。此外，分子生物学的进步使研究人员能够纯化、克隆和修饰过敏原，从而为使用低变应原性修饰蛋白的疫苗研究奠定了基础。最后，还在研究各种非过敏原特异性免疫调节疗法，作为改变对食物过敏原免疫反应的一种手段。随着这些新出现的治疗策略，希望从业者在不久的将来能够为他们的食物过敏患者提供更多的选择。
