Hsu Chia Chun, Chen Pei Yu, Chen Chang Chi, Pan Lung Kwang
Graduate Institute of Radiological Science, Central Taiwan University of Science and Technology, Takun, Taichung 406, Taiwan.
Radiat Prot Dosimetry. 2012 Jul;150(4):405-14. doi: 10.1093/rpd/ncr425. Epub 2011 Nov 16.
The gastric emptying half time (GET) of solid food in 24 healthy volunteers (11M/13F) was evaluated using a revised technique and a gamma camera scan. Within 20 min and after 8 h of fasting, each volunteer ate two pieces of toast with a two-egg-omelette that was mixed with 18.5 MBq (99m)Tc-labelled phytate. The raw data were analysed in the MATLAB program to establish the gastric intestine tract (GI tract) biokinetic model. The GI tract model defines the metabolic mechanism with reference to five compartments, which are stomach, body fluid, small intestine (SI), upper large intestine and lower large intestine, according to the ICRP-30 report. The model was expressed using four simultaneous time-dependent differential equations. The gastric emptying half-time and T(1/2eff)(SI) of males were 62.6±15.4 and 149.8±204.1 min, respectively, and those of females were 98.8±16.3 and 131.6±38.4 min.
采用改良技术和γ相机扫描评估了24名健康志愿者（11名男性/13名女性）固体食物的胃排空半衰期（GET）。在禁食20分钟内及禁食8小时后，每名志愿者食用两片涂有两个鸡蛋煎蛋卷的烤面包，煎蛋卷与18.5 MBq（99m）Tc标记的植酸盐混合。在MATLAB程序中分析原始数据，以建立胃肠道（GI tract）生物动力学模型。根据国际辐射防护委员会（ICRP）-30报告，胃肠道模型参照五个隔室定义代谢机制，这五个隔室分别是胃、体液、小肠（SI）、上大肠和下大肠。该模型用四个同时依赖时间的微分方程表示。男性的胃排空半衰期和小肠有效半衰期（T(1/2eff)(SI)）分别为62.6±15.4分钟和149.8±204.1分钟，女性分别为98.8±16.3分钟和131.6±38.4分钟。
