Grybäck P, Näslund E, Hellström P M, Jacobsson H, Backman L
Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden.
Eur J Nucl Med. 1996 Dec;23(12):1562-7. doi: 10.1007/BF01249617.
It has been suggested that obesity is associated with an altered rate of gastric emptying, and that there are also sex differences in gastric emptying. The results of earlier studies examining gastric emptying rates in obesity and in males and females have proved inconsistent. The aim of this study was to investigate the influence of obesity and gender on gastric emptying, by extending conventional evaluation methods with Kaplan-Meier plots, in order to assess whether these factors have to be accounted for when interpreting results of scintigraphic gastric emptying tests. Twenty-one normal-weight volunteers and nine obese subjects were fed a standardised technetium-99m labelled albumin omelette. Imaging data were acquired at 5- and 10-min intervals in both posterior and anterior projections with the subjects in the sitting position. The half-emptying time, analysed by Kaplan-Meier plot (log-rank test), were shorter in obese subjects compared to normal-weight subjects and later in females compared to males. Also, the lag-phase and half-emptying time were shorter in obese females than in normal females. This study shows an association between different gastric emptying rates and obesity and gender. Therefore, body mass index and gender have to be accounted for when interpreting results of scintigraphic gastric emptying studies.
有人提出，肥胖与胃排空速率改变有关，而且胃排空也存在性别差异。早期研究肥胖人群以及男性和女性胃排空速率的结果并不一致。本研究的目的是通过用Kaplan-Meier曲线扩展传统评估方法，来研究肥胖和性别对胃排空的影响，以便评估在解释闪烁扫描胃排空试验结果时是否必须考虑这些因素。给21名体重正常的志愿者和9名肥胖受试者喂食标准化的锝-99m标记白蛋白煎蛋卷。受试者坐姿时，以5分钟和10分钟的间隔采集后位和前位投影的影像数据。通过Kaplan-Meier曲线（对数秩检验）分析的半排空时间，肥胖受试者比体重正常的受试者短，女性比男性长。此外，肥胖女性的延迟期和半排空时间比正常女性短。本研究表明不同的胃排空速率与肥胖和性别之间存在关联。因此，在解释闪烁扫描胃排空研究结果时必须考虑体重指数和性别。
