Raja Ganesan, Jang Yoon-Kwan, Suh Jung-Soo, Kim Heon-Su, Ahn Sang Hyun, Kim Tae-Jin
Department of Biological Sciences, Pusan National University, Pusan 46241, Korea.
Integrated Biological Science, Pusan National University, Pusan 46241, Korea.
Cancers (Basel). 2020 Mar 12;12(3):664. doi: 10.3390/cancers12030664.
Silver nanoparticles (AgNPs) play significant roles in various cancer cells such as functional heterogeneity, microenvironmental differences, and reversible changes in cell properties (e.g., chemotherapy). There is a lack of targets for processes involved in tumor cellular heterogeneity, such as metabolic clampdown, cytotoxicity, and genotoxicity, which hinders microenvironmental biology. Proteogenomics and chemical metabolomics are important tools that can be used to study proteins/genes and metabolites in cells, respectively. Chemical metabolomics have many advantages over genomics, transcriptomics, and proteomics in anticancer therapy. However, recent studies with AgNPs have revealed considerable genomic and proteomic changes, particularly in genes involved in tumor suppression, apoptosis, and oxidative stress. Metabolites interact biochemically with energy storage, neurotransmitters, and antioxidant defense systems. Mechanobiological studies of AgNPs in cancer metabolomics suggest that AgNPs may be promising tools that can be exploited to develop more robust and effective adaptive anticancer therapies. Herein, we present a proof-of-concept review for AgNPs-based proteogenomics and chemical metabolomics from various tumor cells with the help of several technologies, suggesting their promising use as drug carriers for cancer therapy.
银纳米颗粒（AgNPs）在各种癌细胞中发挥着重要作用，如功能异质性、微环境差异以及细胞特性的可逆变化（如化疗）。肿瘤细胞异质性所涉及的过程，如代谢抑制、细胞毒性和基因毒性，缺乏相关靶点，这阻碍了微环境生物学的发展。蛋白质基因组学和化学代谢组学分别是可用于研究细胞中蛋白质/基因和代谢物的重要工具。在抗癌治疗中，化学代谢组学相对于基因组学、转录组学和蛋白质组学具有许多优势。然而，最近关于AgNPs的研究揭示了相当多的基因组和蛋白质组变化，特别是在与肿瘤抑制、细胞凋亡和氧化应激相关的基因中。代谢物与能量储存、神经递质和抗氧化防御系统发生生化相互作用。AgNPs在癌症代谢组学中的力学生物学研究表明，AgNPs可能是有前景的工具，可用于开发更强大、有效的适应性抗癌疗法。在此，我们借助多种技术对来自各种肿瘤细胞的基于AgNPs的蛋白质基因组学和化学代谢组学进行了概念验证综述，表明它们有望用作癌症治疗的药物载体。
