Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA.
Org Lett. 2011 Dec 16;13(24):6354-7. doi: 10.1021/ol202618t. Epub 2011 Nov 17.
A unified, convenient, and efficient strategy for the preparation of rhodamines and N,N'-diacylated rhodamines has been developed. Fluorescein ditriflates were found to undergo palladium-catalyzed C-N cross-coupling with amines, amides, carbamates, and other nitrogen nucleophiles to provide direct access to known and novel rhodamine derivatives, including fluorescent dyes, quenchers, and latent fluorophores.
已经开发出一种统一、方便、高效的罗丹明和 N,N'-二酰基罗丹明的制备策略。荧光素三氟硫酸盐被发现可以与胺、酰胺、氨基甲酸酯和其他氮亲核试剂进行钯催化的 C-N 交叉偶联，从而直接得到已知和新型的罗丹明衍生物，包括荧光染料、猝灭剂和潜伏荧光团。
