Institute of Dentistry, University of Helsinki, Helsinki, Finland.
J Clin Periodontol. 2011 Nov;38(11):1007-14. doi: 10.1111/j.1600-051X.2011.01775.x. Epub 2011 Sep 15.
We investigated the association of periodontitis and severity of coronary artery disease (CAD) as verified using coronary angiography.
Participants were recruited among those attending coronary angiography at Helsinki University Central Hospital, Finland, in 2007 and 2008. Detailed clinical periodontal examination [number of teeth, bleeding on probing, periodontal probing depth (PPD)] and oral panoramic radiographs [alveolar bone loss (ABL), angular bone defects] were performed.
Of 506 patients, 123 (24.3%) had no significant CAD, whereas 184 (36.4%) had stable CAD and 169 (33.4%) acute coronary syndrome (ACS). Both stable CAD and ACS were associated with 8-17 missing teeth with ORs 4.33 (1.61-11.7, p = 0.020) and 5.24 (1.90-14.5, p = 0.014), and more than seven teeth with PPD ≥6 mm with ORs 2.44 (1.01-6.07, p = 0.049) and 2.75 (1.16-6.53, p = 0.022) respectively. Severe ABL was associated with ACS with an OR 5.39 (1.23-23.6, p = 0.025). Number of stenosed arteries was linearly associated with ABL (p for trend <0.001), number of missing teeth (p < 0.001), and pockets with probing depth ≥6 mm (p = 0.033).
Compared with patients with no significant stenosis, poor periodontal health including missing teeth, periodontal inflammation, and bone loss is associated with angiographically verified coronary artery narrowing in patients with stable CAD or ACS.
我们研究了经冠状动脉造影证实的牙周炎与冠状动脉疾病（CAD）严重程度的相关性。
参与者是在 2007 年至 2008 年期间在芬兰赫尔辛基大学中心医院接受冠状动脉造影的患者中招募的。进行了详细的临床牙周检查[牙齿数量、探诊出血、牙周探诊深度（PPD）]和口腔全景 X 光检查[牙槽骨丧失（ABL）、角型骨缺损]。
在 506 名患者中，123 名（24.3%）无明显 CAD，184 名（36.4%）有稳定型 CAD，169 名（33.4%）有急性冠状动脉综合征（ACS）。稳定型 CAD 和 ACS 均与 8-17 颗缺失牙相关，OR 值分别为 4.33（1.61-11.7，p=0.020）和 5.24（1.90-14.5，p=0.014），以及 PPD≥6mm 的超过 7 颗牙齿，OR 值分别为 2.44（1.01-6.07，p=0.049）和 2.75（1.16-6.53，p=0.022）。严重的 ABL 与 ACS 相关，OR 值为 5.39（1.23-23.6，p=0.025）。狭窄动脉数量与 ABL 呈线性相关（p<0.001）、缺失牙齿数量（p<0.001）和 PPD≥6mm 的牙周袋数量（p=0.033）。
与无明显狭窄的患者相比，稳定型 CAD 或 ACS 患者中，牙周健康状况较差，包括缺失牙齿、牙周炎和骨丧失，与经冠状动脉造影证实的冠状动脉狭窄有关。
