Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
J Clin Periodontol. 2011 Nov;38(11):1015-20. doi: 10.1111/j.1600-051X.2011.01777.x. Epub 2011 Sep 15.
Periodontitis induces overproduction of reactive oxygen species (ROS). This state increases circulating ROS levels and may affect hepatocellular carcinoma (HCC). The Japan Integrated Stage (JIS) score is a novel staging system for HCC. The objective of the present study was to compare JIS scores in HCC patients with and without periodontitis.
We recruited 64 HCC patients comprising 31 chronic periodontitis subjects (HCC + P) and 33 periodontally healthy controls (HCC + H). Their JIS scores were recorded. Serum levels of reactive oxygen metabolites (ROM) from HCC + P, HCC + H and healthy age- and gender-matched subjects with healthy gingiva (control, n = 15) were also assessed for circulating ROS levels.
The HCC + P and HCC + H groups had similar body mass index, habitual drinking and tobacco exposure data. The HCC + P group showed higher JIS scores than the HCC + H group (p = 0.027). Both the HCC + P and HCC + H groups had higher serum levels of ROM than controls (p < 0.001), while serum levels of ROM in the HCC + P group were a further 25.8% higher than those in the HCC + H group (p < 0.001).
HCC patients with periodontitis had higher JIS score and circulating ROS level than HCC patients without periodontitis.
牙周炎可导致活性氧（ROS）过度产生。这种状态会增加循环 ROS 水平，并可能影响肝细胞癌（HCC）。日本综合分期（JIS）评分是一种新型 HCC 分期系统。本研究旨在比较伴或不伴牙周炎的 HCC 患者的 JIS 评分。
我们招募了 64 名 HCC 患者，包括 31 名慢性牙周炎患者（HCC+P）和 33 名牙周健康对照者（HCC+H）。记录他们的 JIS 评分。还评估了 HCC+P、HCC+H 和健康牙龈的健康年龄和性别匹配对照者（n=15）的血清活性氧代谢物（ROM）水平，以评估循环 ROS 水平。
HCC+P 和 HCC+H 两组的体重指数、习惯性饮酒和吸烟暴露数据相似。HCC+P 组的 JIS 评分高于 HCC+H 组（p=0.027）。HCC+P 和 HCC+H 组的血清 ROM 水平均高于对照组（p<0.001），而 HCC+P 组的血清 ROM 水平比 HCC+H 组高 25.8%（p<0.001）。
伴牙周炎的 HCC 患者的 JIS 评分和循环 ROS 水平高于不伴牙周炎的 HCC 患者。
