Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Tehran, Iran.
J Viral Hepat. 2011 Dec;18(12):821-30. doi: 10.1111/j.1365-2893.2011.01530.x. Epub 2011 Oct 13.
Autophagy is a very tightly regulated process that is important in many cellular processes including development, differentiation, survival and homoeostasis. The importance of this process has already been proven in numerous common diseases such as cancer and neurodegenerative disorders. Emerging data indicate that autophagy plays an important role in some liver diseases including liver injury induced by ischaemia reperfusion and alpha-1 antitrypsin Z allele-dependent liver disease. Autophagy may also occur in viral infection, and it may play a crucial role in antimicrobial host defence against pathogens, while supporting cellular homoeostasis processes. Here, the latest findings on the role of autophagy in viral hepatitis B and C infection, which are both serious health threats, will be reviewed.
自噬是一个受到严格调控的过程，在包括发育、分化、存活和动态平衡在内的许多细胞过程中都很重要。这一过程的重要性已在许多常见疾病中得到证实，如癌症和神经退行性疾病。新出现的数据表明，自噬在某些肝脏疾病中发挥着重要作用，包括缺血再灌注引起的肝损伤和α-1 抗胰蛋白酶 Z 等位基因依赖性肝病。自噬也可能发生在病毒感染中，它可能在对抗病原体的抗菌宿主防御中发挥关键作用，同时支持细胞动态平衡过程。在此，我们将回顾自噬在乙型和丙型病毒性肝炎感染中的最新发现，这两种肝炎都是严重的健康威胁。
