自噬：病毒感染与宿主细胞之间的多功能桥梁。
Autophagy: The multi-purpose bridge in viral infections and host cells.
机构信息
Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
出版信息
Rev Med Virol. 2018 Jul;28(4):e1973. doi: 10.1002/rmv.1973. Epub 2018 Apr 30.
Abstract
Autophagy signaling pathway is involved in cellular homeostasis, developmental processes, cellular stress responses, and immune pathways. The aim of this review is to summarize the relationship between autophagy and viruses. It is not possible to be fully comprehensive, or to provide a complete "overview of all viruses". In this review, we will focus on the interaction of autophagy and viruses and survey how human viruses exploit multiple steps in the autophagy pathway to help viral propagation and escape immune response. We discuss the role that macroautophagy plays in cells infected with hepatitis C virus, hepatitis B virus, rotavirus gastroenteritis, immune cells infected with human immunodeficiency virus, and viral respiratory tract infections both influenza virus and coronavirus.
摘要
自噬信号通路参与细胞内稳态、发育过程、细胞应激反应和免疫途径。本综述的目的是总结自噬与病毒之间的关系。由于不可能做到完全全面，也无法提供所有病毒的“全面概述”。在本综述中，我们将重点关注自噬与病毒的相互作用，并调查人类病毒如何利用自噬途径的多个步骤来帮助病毒的繁殖和逃避免疫反应。我们讨论了巨自噬在感染丙型肝炎病毒、乙型肝炎病毒、轮状病毒肠胃炎、感染人类免疫缺陷病毒的免疫细胞以及呼吸道病毒感染（流感病毒和冠状病毒）的细胞中的作用。
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