Imai Eri, Tsuji Tomiko, Sano Mitsue, Fukuwatari Tsutomu, Shibata Katsumi
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan.
Asia Pac J Clin Nutr. 2011;20(4):507-13.
The objective is to determine the association between the 24 hour urinary α-tocopherol catabolite, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and α-tocopherol intake in an intervention and a cross-sectional studies. In the 4-weeks intervention study, Japanese men (n = 10) consumed the test diet in week 1, and the test diet plus varying amounts of α-tocopherol in the three subsequent weeks: 21 μmol/d α-tocopherol in week 2, 63 μmol/d in week 3, and 125 μmol/d in week 4. A significant association between α-tocopherol intake and urinary α-CEHC was observed in this strictly controlled experiment (r = 0.99, p<0.001). In the cross-sectional study, all foods consumed over 4 consecutive days were recorded in 76 free-living young subjects (18-33 years). The association was weak, but a significant relationship was observed (r = 0.29, p<0.05) even in the cross-sectional study. In the cross-sectional study adults, mean estimated α-tocopherol intake calculated by urinary α-CEHC and the excretory ratio was 91% of their mean intake over the 4 days. The results show that urinary α-CEHC level reflected recent α-tocopherol intake in free-living young Japanese adults, and could be used as a measure of intake during the previous few days, both for group means and for individual rankings within a group.
目的是在一项干预研究和一项横断面研究中，确定24小时尿α-生育酚分解代谢物2,5,7,8-四甲基-2(2'-羧乙基)-6-羟基色满（α-CEHC）与α-生育酚摄入量之间的关联。在为期4周的干预研究中，10名日本男性在第1周食用试验饮食，在随后的三周中食用试验饮食并添加不同量的α-生育酚：第2周为21μmol/dα-生育酚，第3周为63μmol/d，第4周为125μmol/d。在这个严格控制的实验中观察到α-生育酚摄入量与尿α-CEHC之间存在显著关联（r = 0.99，p<0.001）。在横断面研究中，记录了76名自由生活的年轻受试者（18 - 33岁）连续4天摄入的所有食物。这种关联较弱，但即使在横断面研究中也观察到了显著关系（r = 0.29，p<0.05）。在横断面研究的成年人中，通过尿α-CEHC和排泄率计算的平均估计α-生育酚摄入量为他们4天平均摄入量的91%。结果表明，尿α-CEHC水平反映了自由生活的年轻日本成年人近期的α-生育酚摄入量，并且可作为前几天摄入量的一种衡量指标，用于群体均值以及群体内个体排名。
