Eftekhari Mohammad Hassan, Akbarzadeh Marzieh, Dabbaghmanesh Mohammad Hossein, Hasanzadeh Jafar
Nutrition Department, Research Center for Health Sciences, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz. I.R. Iran.
Asia Pac J Clin Nutr. 2011;20(4):521-6.
Type 2 diabetes is a major public health problem. Recent epidemiological evidence also points to a potential association of vitamin D insufficiency with adverse metabolic risks, including that for type 2 diabetes.
A double-blind randomized placebo-controlled trial was carried out. Seventy subjects with type 2 diabetes, age 30-75 years old, were randomly assigned in a double-blind fashion to two groups. One group received two capsules of calcitriol (0.25 μg 1,25-dihydroxy cholecalciferol per each capsule) per day. The second group received placebo tablets. At the beginning, middle and the end of the 12 week supplementation trial, serum glucose, insulin, calcium and phosphorous, HbA1c and 25(OH) vitamin D were measured.
There was no significant difference between two groups at baseline. At the end of the study, fasting plasma glucose increased in the control group (p=0.038), while it remained unchanged in calcitriol group. Level of insulin and HbA1c increased significantly in both groups (p=0.013 and 0.0004 in treatment and control group). Regarding insulin resistance indices, there was a significant change in HOMA-IR and QUICKI in both groups (p=0.023 and 0.002 in treatment and 0.001 and <0.001 in control group respectively). Insulin secretion as assessed by HOMA-%β, remained relatively unchanged in the control group, while it increased significantly in the treatment group at the end of study (p=0.009).
Vitamin D supplementation attenuated the increase in glycemia, and increased insulin secretion, but had no effect on insulin resistance.
2型糖尿病是一个主要的公共卫生问题。最近的流行病学证据也表明维生素D不足与不良代谢风险之间存在潜在关联，包括2型糖尿病的风险。
进行了一项双盲随机安慰剂对照试验。70名年龄在30至75岁之间的2型糖尿病患者以双盲方式随机分为两组。一组每天服用两粒骨化三醇胶囊（每粒含0.25μg 1,25 - 二羟基胆钙化醇）。第二组服用安慰剂片。在为期12周的补充试验开始、中期和结束时，测量血清葡萄糖、胰岛素、钙和磷、糖化血红蛋白A1c以及25(OH)维生素D。
两组在基线时无显著差异。研究结束时，对照组空腹血糖升高（p = 0.038），而骨化三醇组保持不变。两组胰岛素和糖化血红蛋白A1c水平均显著升高（治疗组和对照组分别为p = 0.013和0.0004）。关于胰岛素抵抗指数，两组的稳态模型评估胰岛素抵抗（HOMA - IR）和定量胰岛素敏感性检查指数（QUICKI）均有显著变化（治疗组分别为p = 0.023和0.002，对照组分别为0.001和<0.001）。通过稳态模型评估的胰岛β细胞功能百分比（HOMA - %β）评估的胰岛素分泌，在对照组相对保持不变，而在研究结束时治疗组显著增加（p = 0.009）。
补充维生素D可减轻血糖升高，并增加胰岛素分泌，但对胰岛素抵抗无影响。
