Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran; Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran; Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Complement Ther Med. 2019 Apr;43:283-288. doi: 10.1016/j.ctim.2019.03.001. Epub 2019 Mar 2.
The prevalence of type 2 diabetes has risen dramatically in recent years. There are many different safe therapies used for diabetes and also number of natural supplements that can be used to manage diabetes. We assessed the effect of oral propolis supplementation on blood glucose, insulin resistance and antioxidant status in type 2 diabetes.
We conducted a randomized, double-blinded, placebo-controlled trial for 8-week. Sixty two patients with type 2 diabetes (30-55 years of age) were randomly assigned in two group, propolis (n = 31) and placebo (n = 31). Patients were given doses of 500 mg, three times a day (1500 mg), of propolis or placebo three time a day. The fasting blood sugar (FBS), two-hour postprandial glucose (2-hp), insulin, insulin resistance (IR), hemoglobin Ac (HbAc), total antioxidant capacity (TAC) and activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) were measured at the beginning and end of the study. Statistical analysis was performed using SPSS software.
After two month, FBS, 2-hp, insulin, IR, HbAc was significantly decreased in patients treated with propolis compared with placebo group (p < 0.05). Additionally intake of propolis significantly increased the blood levels of TAC and activity of GPx and SOD (p < 0.05).
Propolis treatment can be helpful as a diet supplement in patients with type 2 diabetes through improvement in glycemic status, reduction in insulin resistance and amelioration in antioxidant status. This supplement without side effects can increase the effectiveness of prescribing drugs in diabetes.
近年来，2 型糖尿病的患病率急剧上升。有许多不同的安全疗法可用于糖尿病，也有许多天然补充剂可用于治疗糖尿病。我们评估了口服蜂胶补充剂对 2 型糖尿病患者血糖、胰岛素抵抗和抗氧化状态的影响。
我们进行了为期 8 周的随机、双盲、安慰剂对照试验。62 例 2 型糖尿病患者（30-55 岁）被随机分为两组，蜂胶组（n=31）和安慰剂组（n=31）。患者每天服用 3 次，每次 500mg（共 1500mg）蜂胶或安慰剂。在研究开始和结束时测量空腹血糖（FBS）、餐后 2 小时血糖（2-hp）、胰岛素、胰岛素抵抗（IR）、糖化血红蛋白（HbAc）、总抗氧化能力（TAC）和谷胱甘肽过氧化物酶（GPx）和超氧化物歧化酶（SOD）的活性。统计分析采用 SPSS 软件进行。
与安慰剂组相比，蜂胶治疗 2 个月后，FBS、2-hp、胰岛素、IR、HbAc 显著降低（p<0.05）。此外，蜂胶的摄入显著增加了血液 TAC 水平以及 GPx 和 SOD 的活性（p<0.05）。
蜂胶治疗可作为 2 型糖尿病患者的饮食补充剂，通过改善血糖状态、降低胰岛素抵抗和改善抗氧化状态来帮助患者。这种无副作用的补充剂可以提高糖尿病患者药物治疗的效果。
