Salo Ruth, Fassbender Catherine
UC Davis Imaging Research Center, 4701 X Street, Sacramento, CA, USA,
Curr Top Behav Neurosci. 2012;11:321-64. doi: 10.1007/7854_2011_172.
This chapter reviews selected neuroimaging findings related to long-term amphetamine and methamphetamine (MA) use. An overview of structural and functional (fMRI) MR studies, Diffusion Tensor Imaging (DTI), Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies conducted in long-term MA abusers is presented. The focus of this chapter is to present the relevant studies as tools to understand brain changes following drug abstinence and recovery from addiction. The behavioral relevance of these neuroimaging studies is discussed as they relate to clinical symptoms and treatment. Within each imaging section this chapter includes a discussion of the relevant imaging studies as they relate to patterns of drug use (i.e., duration of MA use, cumulative lifetime dose and time MA abstinent) as well as an overview of studies that link the imaging findings to cognitive measures. In our conclusion we discuss some of the future directions of neuroimaging as it relates to the pathophysiology of addiction.
本章回顾了与长期使用苯丙胺和甲基苯丙胺（MA）相关的神经影像学研究结果。介绍了针对长期MA滥用者进行的结构和功能（功能磁共振成像）磁共振研究、扩散张量成像（DTI）、磁共振波谱（MRS）和正电子发射断层扫描（PET）研究的概况。本章重点是将相关研究作为理解药物戒断和成瘾恢复后脑变化的工具进行呈现。这些神经影像学研究与临床症状和治疗相关的行为相关性也会进行讨论。在每个成像部分中，本章会讨论相关成像研究与药物使用模式（即MA使用时长、累积终生剂量和MA戒断时间）的关系，以及将成像结果与认知测量联系起来的研究概述。在结论部分，我们将讨论神经影像学在成瘾病理生理学方面的一些未来发展方向。
