Janetsian Sarine S, McCane Aqilah M, Linsenbardt David N, Lapish Christopher C
aIndiana University-Purdue University Indianapolis, Department of Psychology bIndiana University-Purdue University Indianapolis, School of Science, Institute for Mathematical Modeling and Computational Science cIndiana University School of Medicine, Stark Neuroscience Research Institute, Indianapolis, Indiana, USA.
Behav Pharmacol. 2015 Dec;26(8 Spec No):786-97. doi: 10.1097/FBP.0000000000000158.
The purpose of the current study was to assess social interaction (SI) following acute and repeated methamphetamine (MA) administration. Rats were injected with 5.0 mg/kg of MA and SI was tested 30 min or 24 h later. In another group of animals, MA sensitization was induced using 5.0 mg/kg of MA, and SI was assessed after 1 or 30 days of abstinence. SI was reduced in rats injected with MA 30 min, but not 24 h, before testing, compared with saline controls. Impaired SI was observed in combination with active avoidance of the conspecific animal. Repeated injections of MA progressively reduced locomotor activity and increased stereotypy, indicating that animals were sensitized. However, no differences in SI were observed 24 h or 30 days following the induction of sensitization. The absence of detectable differences in SI following MA sensitization may be attributable to the relatively short regimen used to induce sensitization. However, the current series of experiments provides evidence that an acute injection of MA decreases SI and simultaneously increases avoidance behavior, which supports a link between psychostimulant use and impaired social functioning. These data suggest that the acute injection model may provide a useful model to explore the neural basis of impaired social functioning and antisocial behavior.
本研究的目的是评估急性和重复给予甲基苯丙胺（MA）后的社会互动（SI）。给大鼠注射5.0mg/kg的MA，并在30分钟或24小时后测试SI。在另一组动物中，使用5.0mg/kg的MA诱导MA敏化，并在禁欲1天或30天后评估SI。与生理盐水对照组相比，在测试前30分钟注射MA的大鼠SI降低，但24小时注射MA的大鼠SI未降低。观察到SI受损并伴有主动回避同种动物。重复注射MA逐渐降低运动活性并增加刻板行为，表明动物产生了敏化。然而，在诱导敏化后24小时或30天未观察到SI的差异。MA敏化后SI未检测到差异可能归因于用于诱导敏化的方案相对较短。然而，当前系列实验提供了证据，即急性注射MA会降低SI并同时增加回避行为，这支持了精神兴奋剂使用与社会功能受损之间的联系。这些数据表明，急性注射模型可能为探索社会功能受损和反社会行为的神经基础提供有用的模型。
