Department of Geriatric Psychiatry, Akershus University Hospital, Lorenskog, Norway.
Dement Geriatr Cogn Disord. 2011;32(3):202-8. doi: 10.1159/000333072. Epub 2011 Nov 16.
BACKGROUND/AIMS: To explore the presenting and early symptoms of dementia with Lewy bodies (DLB).
Patients with mild dementia fulfilling diagnostic criteria for DLB (n = 61) and Alzheimer's disease (AD) (n = 109) were recruited from outpatient dementia clinics in western Norway. At diagnosis, caregivers were asked which symptom had been the presenting symptom of dementia.
Caregivers reported that memory impairment was the most common presenting symptom in DLB (57%), followed by visual hallucinations (44%), depression (34%), problem solving difficulties (33%), gait problems (28%), and tremor/stiffness (25%). In contrast, 99% of AD carers reported impaired memory as a presenting symptom, whereas visual hallucinations were a presenting symptom in 3% of the AD cases.
DLB should be suspected in predementia cases with visual hallucinations.
背景/目的:探索路易体痴呆(DLB)的发病表现和早期症状。
从挪威西部的门诊痴呆诊所招募了符合 DLB(n=61)和阿尔茨海默病(AD)(n=109)诊断标准的轻度痴呆患者。在诊断时,护理人员被问及哪种症状是痴呆的首发症状。
护理人员报告说,记忆障碍是 DLB 最常见的首发症状(57%),其次是视觉幻觉(44%)、抑郁(34%)、解决问题困难(33%)、步态问题(28%)和震颤/僵硬(25%)。相比之下,99%的 AD 患者的护理人员报告记忆障碍是首发症状,而 3%的 AD 患者的首发症状是视觉幻觉。
对于有视觉幻觉的前驱期痴呆患者,应怀疑为 DLB。