[二氧化钛涂层生物医用镍钛形状记忆合金的血液相容性研究]

[Study of blood compatibility on TiO2 coated biomedical Ni-Ti shape memory alloy].

作者信息

Gao Shuchun, Zhai Yuchun, Hu Jinling

机构信息

Academiy of Metallurgy and Material, Northeastern University, Shenyang 110004, China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2011 Oct;28(5):968-71, 1000.

PMID:22097265

Abstract

We coated a thin TiO2 film on the surface of Ni-Ti shape memory alloy by activated sputter method in the present work. The blood platelet adherence and antithrombogenicity of the TiO2-coated Ni-Ti alloy were evaluated. The results showed that the platelets on the TiO2-coated Ni-Ti alloy were fewer than those on 316L stainless steel, and no agglomeration or distortion for the platelets on the coated alloy was found, which means less probability of blood coagulation for the alloy. The coagulation time on the coated Ni-Ti shape memory alloy was longer than that on the 316L. Compared with that on the 316L stainless steel, the TiO2 coated Ni-Ti shape memory alloy showed better blood compatibility, indicating that the Ni-Ti alloy with TiO2 coating is a kind of ideal biomedical materials with high clinical value.

摘要

在本工作中，我们通过活性溅射法在镍钛形状记忆合金表面涂覆了一层TiO₂薄膜。对涂覆TiO₂的镍钛合金的血小板粘附性和抗血栓形成性进行了评估。结果表明，涂覆TiO₂的镍钛合金上的血小板比316L不锈钢上的少，并且未发现涂覆合金上的血小板有团聚或变形现象，这意味着该合金发生血液凝固的可能性较小。涂覆镍钛形状记忆合金的凝血时间比316L的长。与316L不锈钢相比，涂覆TiO₂的镍钛形状记忆合金表现出更好的血液相容性，表明涂覆TiO₂的镍钛合金是一种具有高临床价值的理想生物医学材料。