对感染人类免疫缺陷病毒的无症状患者弓形虫病患病率的血清学研究。
Serological study of the prevalence of toxoplasmosis in asymptomatic patients infected with human immunodeficiency virus.
作者信息
Holliman R E
机构信息
Public Health Laboratory Service, St George's Hospital, London.
出版信息
Epidemiol Infect. 1990 Oct;105(2):415-8. doi: 10.1017/s0950268800047993.
Abstract
Asymptomatic individuals seropositive for antibody to human immunodeficiency virus (HIV) were investigated for the presence of toxoplasma specific antibody. Serological examination was performed using multiple assays. Of 500 patients studied 133 had serological evidence of previous exposure to Toxoplasma gondii. Specific IgM was detected in 7 patients using ISAGA and 2 patients by DS-ELISA. The immunoglobulin-G annual seroconversion rate was calculated to be 0.75%. The results of this study indicate 27% of HIV positive patients in the UK are at risk of developing life-threatening secondary reactivation of cerebral toxoplasmosis in association with AIDS. A further 0.5-1% per year may suffer primary toxoplasmosis.
摘要
对人类免疫缺陷病毒（HIV）抗体呈血清阳性的无症状个体进行了弓形虫特异性抗体检测。采用多种检测方法进行血清学检查。在研究的500名患者中，有133名有既往接触过刚地弓形虫的血清学证据。使用ISAGA在7名患者中检测到特异性IgM，通过DS-ELISA在2名患者中检测到。免疫球蛋白G的年血清转化率经计算为0.75%。本研究结果表明，英国27%的HIV阳性患者有因艾滋病而发生危及生命的脑弓形虫病继发性再激活的风险。每年另有0.5%-1%的患者可能会患原发性弓形虫病。
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本文引用的文献
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Discrepant toxoplasma latex agglutination test results.弓形虫乳胶凝集试验结果不一致。
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Direct agglutination test and other assays for measuring antibodies to Toxoplasma gondii.直接凝集试验及其他检测弓形虫抗体的检测方法。
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