Nanjing University School of Medicine, Jinling Hospital, Department of Neurology, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China.
Expert Opin Drug Deliv. 2011 Dec;8(12):1681-90. doi: 10.1517/17425247.2011.633508.
The intranasal delivery of therapeutics to the brain has achieved great success in preclinical studies. These findings are important because there are many neurological disorders without feasible treatments, due to a lack of effective drug delivery methods to the brain. Translating such intranasal delivery strategies from bench to bedside is an important step for curing these neurological diseases.
This review summarizes recent clinical trials that have investigated the intranasal delivery of drugs to the brain to treat neurological disorders and their potential mechanisms of action. In addition, the potential opportunities as well as challenges of intranasal delivery in clinical trials are discussed.
The intranasal delivery of drugs to the brain is a novel method with great potential, and it may provide an extraordinary approach to overcome the existing barriers of drug delivery for treating some neurological disorders. Intranasal delivery of central nervous system therapeutics has shown promise in several clinical trials, which demonstrates both the need and importance of further research.
将治疗药物经鼻腔递送至大脑在临床前研究中取得了巨大成功。这些发现非常重要，因为有许多神经疾病没有可行的治疗方法，这是由于缺乏有效的药物递送至大脑的方法。将此类鼻腔递药策略从实验室转化为临床应用是治疗这些神经疾病的重要步骤。
本综述总结了最近的临床试验，这些临床试验研究了经鼻腔将药物递送至大脑以治疗神经疾病及其潜在的作用机制。此外，还讨论了鼻腔给药在临床试验中的潜在机遇和挑战。
将药物经鼻腔递送至大脑是一种具有巨大潜力的新方法，它可能为克服某些神经疾病药物递送的现有障碍提供一种非凡的方法。几种临床前研究表明，中枢神经系统治疗药物的鼻腔给药具有良好的前景，这既表明了进一步研究的必要性，也凸显了其重要性。
