Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, 325000, PR China; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University, Wenzhou City, Zhejiang Province, 325000, PR China.
Center for Neuroscience Discovery, Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX 76107, USA; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University, Wenzhou City, Zhejiang Province, 325000, PR China.
Prog Neurobiol. 2017 Oct;157:29-48. doi: 10.1016/j.pneurobio.2017.07.003. Epub 2017 Jul 22.
The effectiveness of noninvasive treatment for neurological disease is generally limited by the poor entry of therapeutic agents into the central nervous system (CNS). Most CNS drugs cannot permeate into the brain parenchyma because of the blood-brain barrier thus, overcoming this problem has become one of the most significant challenges in the development of neurological therapeutics. Nanotechnology has emerged as an innovative alternative for treating neurological diseases. In fact, rapid advances in nanotechnology have provided promising solutions to this challenge. This review highlights the applications of nanomaterials in the developing neurological field and discusses the evidence for their efficacies.
非侵入性治疗神经疾病的效果通常受到治疗剂进入中枢神经系统 (CNS) 的能力差的限制。由于血脑屏障,大多数 CNS 药物无法渗透到脑实质中,因此克服这个问题已成为神经治疗学发展的最重大挑战之一。纳米技术已成为治疗神经疾病的一种创新选择。事实上,纳米技术的快速发展为这一挑战提供了有前途的解决方案。本综述强调了纳米材料在神经科学领域的应用,并讨论了其疗效的证据。