Department Chemie, Ludwig-Maximilians-Universität, Butenandtstrasse, 5-13, 81377 München, Germany.
Org Lett. 2011 Dec 16;13(24):6440-3. doi: 10.1021/ol202733v. Epub 2011 Nov 18.
The reaction of commercial Al-powder (3 equiv) and InCl(3) (1-5 mol %) with benzylic chlorides provides various functionalized benzylic aluminum sesquichlorides under mild conditions (THF, 20 °C, 3-24 h) without homocoupling (<5%). These new benzylic organometallics reacted smoothly with various electrophiles (Pd-catalyzed cross-couplings, or Cu-mediated acylations, allylations, or 1,4-addition reactions). Electron-poor benzylic chlorides or substrates prone to Wurtz coupling can be converted to benzylic zinc compounds by the reaction of Al-powder in the presence of ZnCl(2).
商业铝粉（3 当量）和 InCl3（1-5 mol%）与苄基氯化物反应，在温和条件下（THF，20°C，3-24 小时）提供各种功能化的苄基铝倍半氯化物，没有偶联（<5%）。这些新的苄基有机金属化合物与各种亲电试剂（Pd 催化交叉偶联，或 Cu 介导的酰化、烯丙基化或 1,4-加成反应）反应平稳。在 ZnCl2 的存在下，通过铝粉的反应，可以将缺电子的苄基氯化物或容易发生武兹偶联的底物转化为苄基锌化合物。
