Biology Department, MS #32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, United States.
Aquat Toxicol. 2011 Oct;105(3-4 Suppl):67-71. doi: 10.1016/j.aquatox.2011.06.001. Epub 2011 Jun 12.
On the 30th anniversary of the journal, I provide a perspective on some of the questions and opportunities for new understanding that will interest aquatic toxicologists during the next 30 years. I focus on mechanisms of toxicity involving transcription factors, signalling pathways, and gene networks involved in toxic and adaptive responses in aquatic animals. Prominent questions address the value of a toxicity pathways approach in aquatic systems, issues involving extrapolation among species, identification of susceptibility genes and useful biomarkers of adverse effect, new emerging contaminants, the importance of epigenetic mechanisms, effects of multiple stressors, evolutionary toxicology, and the relative roles of technical and conceptual limitations to our understanding of chemical effects on aquatic systems.
在该期刊创刊 30 周年之际，我提供了一些观点，探讨了在未来 30 年内水生毒理学家可能感兴趣的问题和新的理解机会。我重点关注涉及转录因子、信号通路和基因网络的毒性作用机制，这些机制涉及水生动物的毒性和适应性反应。主要问题涉及毒性途径方法在水生系统中的价值、物种间推断涉及的问题、易感性基因的鉴定以及不良影响的有用生物标志物、新出现的污染物、表观遗传机制的重要性、多种胁迫因素的影响、进化毒理学以及我们对化学物质对水生系统影响的理解的技术和概念限制的相对作用。
