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气味物体的皮质处理。

Cortical processing of odor objects.

机构信息

Emotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.

出版信息

Neuron. 2011 Nov 17;72(4):506-19. doi: 10.1016/j.neuron.2011.10.027.

DOI:10.1016/j.neuron.2011.10.027
PMID:22099455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3223720/
Abstract

Natural odors, generally composed of many monomolecular components, are analyzed by peripheral receptors into component features and translated into spatiotemporal patterns of neural activity in the olfactory bulb. Here, we will discuss the role of the olfactory cortex in the recognition, separation and completion of those odor-evoked patterns, and how these processes contribute to odor perception. Recent findings regarding the neural architecture, physiology, and plasticity of the olfactory cortex, principally the piriform cortex, will be described in the context of how this paleocortical structure creates odor objects.

摘要

天然气味通常由许多单分子成分组成,通过外周受体将其分析成成分特征,并转化为嗅球中神经活动的时空模式。在这里,我们将讨论嗅皮层在识别、分离和完成这些气味诱发模式中的作用,以及这些过程如何有助于气味感知。本文将主要描述梨状皮层等古皮层结构如何创建气味物体,讨论嗅皮层的神经结构、生理学和可塑性的最新发现。

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Neuron. 2011 Nov 17;72(4):506-19. doi: 10.1016/j.neuron.2011.10.027.
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本文引用的文献

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Central olfactory structures.中枢嗅觉结构
Handb Clin Neurol. 2019;164:79-96. doi: 10.1016/B978-0-444-63855-7.00006-X.
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Genetic visualization of the secondary olfactory pathway in Tbx21 transgenic mice.Tbx21转基因小鼠中次级嗅觉通路的基因可视化
Neural Syst Circuits. 2011 Feb 1;1(1):5. doi: 10.1186/2042-1001-1-5.
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Daily rhythms in olfactory discrimination depend on clock genes but not the suprachiasmatic nucleus.嗅觉辨别能力的日常节律依赖于时钟基因而非视交叉上核。
通过平行的、基因不同的基底外侧杏仁核通路将负面情绪状态导向腹侧纹状体亚区域。
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Exploring the feasibility of olfactory brain-computer interfaces.探索嗅觉脑机接口的可行性。
Sci Rep. 2025 May 26;15(1):18404. doi: 10.1038/s41598-025-01488-z.
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Olfactory dysfunction and altered cortical excitability in the mouse model of Fragile X Syndrome.脆性X综合征小鼠模型中的嗅觉功能障碍与皮质兴奋性改变
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Representational learning by optimization of neural manifolds in an olfactory memory network.通过优化嗅觉记忆网络中的神经流形进行表征学习。
Res Sq. 2025 Mar 26:rs.3.rs-6155477. doi: 10.21203/rs.3.rs-6155477/v1.
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Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top-Down Circuit.前梨状皮层在通过自上而下的神经回路介导社交新奇性输出中的重要作用。
Adv Sci (Weinh). 2025 Apr;12(13):e2406192. doi: 10.1002/advs.202406192. Epub 2025 Feb 14.
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Olfactory testing in infants with perinatal asphyxia: Enhancing encephalopathy risk stratification for future health outcomes.围产期窒息婴儿的嗅觉测试:加强对未来健康结局的脑病风险分层
Neurosci Biobehav Rev. 2025 Feb;169:106029. doi: 10.1016/j.neubiorev.2025.106029. Epub 2025 Jan 26.
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Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal.在规则反转过程中,从梨状皮质到嗅球的快速更新反馈传递多模态身份和奖励意外信号。
Nat Commun. 2025 Jan 22;16(1):937. doi: 10.1038/s41467-025-56023-5.
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Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex.与嗅觉皮层相关的精确平衡记忆网络中表征的几何结构与动力学
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J Biol Rhythms. 2011 Dec;26(6):552-60. doi: 10.1177/0748730411420247.
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Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model.阿尔茨海默病β-淀粉样蛋白模型中的感觉网络功能障碍、行为损伤及其可逆性。
J Neurosci. 2011 Nov 2;31(44):15962-71. doi: 10.1523/JNEUROSCI.2085-11.2011.
5
Recurrent circuitry dynamically shapes the activation of piriform cortex.内侧嗅皮层的激活受反复出现的回路动态调节。
Neuron. 2011 Oct 6;72(1):49-56. doi: 10.1016/j.neuron.2011.08.020.
6
A major role for intracortical circuits in the strength and tuning of odor-evoked excitation in olfactory cortex.皮质内回路在嗅觉皮层中增强和调整气味诱发兴奋中的主要作用。
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Cell. 2011 Sep 16;146(6):1004-15. doi: 10.1016/j.cell.2011.07.041.
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Olfactory cortex generates synchronized top-down inputs to the olfactory bulb during slow-wave sleep.嗅觉皮层在慢波睡眠期间向嗅球产生同步的自上而下的输入。
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