Department of Pediatrics, Baystate Medical Center/Tufts University School of Medicine, Boston, MA, USA.
J Pediatr. 2012 Apr;160(4):615-620.e2. doi: 10.1016/j.jpeds.2011.09.051. Epub 2011 Nov 17.
To examine the relationship between urinary pH and metabolic syndrome risk factors along with insulin resistance in obese adolescents, and to evaluate the relationship between other urinary stone-forming and -inhibiting markers and metabolic syndrome.
A total of 46 obese adolescents were enrolled. Twenty-four hour and randomly obtained urine samples were analyzed for urinary pH, promoters of stone formation (ie, uric acid, oxalate, and relative saturation ratio of calcium oxalate [RSR-CaOx]), and inhibitors of stone formation (ie, citrate and osteopontin). Other data collected included height, weight, blood pressure, and fasting lipid, insulin, and glucose levels.
The subjects had a mean age of 14.6±2.0 years and a mean body mass index of 36±6.3 kg/m(2). Random urine pH and the number of risk factors for metabolic syndrome were negatively correlated (r=-0.34; P=.02). RSR-CaOx was correlated with both homeostasis model assessment of insulin resistance score (r=0.38; P<.01) and number of risk factors for metabolic syndrome (r=0.47; P=.001)
Decreased urinary pH and increased RSR-CaOx are associated with risk factors for metabolic syndrome in obese adolescents.
研究肥胖青少年尿 pH 值与代谢综合征相关危险因素及胰岛素抵抗的关系，并评估其他尿结石形成和抑制标志物与代谢综合征的关系。
共纳入 46 名肥胖青少年。分析 24 小时和随机尿样的尿 pH 值、结石形成促进剂（即尿酸、草酸和草酸钙相对饱和度比 [RSR-CaOx]）和结石抑制剂（即柠檬酸和骨桥蛋白）。收集的其他数据包括身高、体重、血压以及空腹血脂、胰岛素和血糖水平。
受试者的平均年龄为 14.6±2.0 岁，平均体重指数为 36±6.3kg/m2。随机尿 pH 值与代谢综合征的危险因素数量呈负相关（r=-0.34；P=.02）。RSR-CaOx 与稳态模型评估的胰岛素抵抗评分（r=0.38；P<.01）和代谢综合征的危险因素数量（r=0.47；P=.001）均呈正相关。
肥胖青少年尿 pH 值降低和 RSR-CaOx 增加与代谢综合征的危险因素相关。
