Comprehensive Pediatrics & Pulmonary and Critical Care Medicine, Kunming Children's Hospital, No.28, Shulin Street, Kunming, 650103, Yunnan Province, China.
Pediatric Department, Qionghai People's Hospital, No.33, Fuhai Road, Qionghai, 571400, Hainan Province, China.
Sci Rep. 2024 Jun 10;14(1):13248. doi: 10.1038/s41598-024-64073-w.
Blood urea nitrogen (BUN) level is one of the commonly used indicators to assess renal function and systemic immune-inflammatory status. In the adolescent population, changes in BUN levels may be associated with a variety of factors, including physiologic dehydration, lifestyle influences such as nutritional intake, physical activity, and possible endocrine or metabolic disorders. In recent years, more and more studies have shown that BUN levels are not only a reflection of kidney function, but it may also be related to the inflammatory state of the body. The Systemic Immune Inflammatory Index (SII) is a comprehensive index that takes into account platelet counts, neutrophil and lymphocyte counts, and is thought to be effective in reflecting the body's immune status and inflammatory response. However, research on the relationship between the two, SII and BUN, remains understudied in the adolescent population. The purpose of this study was to examine the relationship between SII and BUN levels in a population of American adolescents and to further analyze the factors that influence it. We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) database. Using descriptive statistics, correlation analysis, and regression analysis, we explored the relationship between SII and BUN levels. We found a significant negative correlation between SII and BUN levels, with BUN levels decreasing when SII levels increased (BUN as the dependent variable and SII as the outcome variable). We performed a multiple regression analysis of this relationship, controlling for possible confounders such as gender, age, race, and BMI, and found that this negative correlation remained significant. Our findings reveal an important relationship between SII and BUN levels and provide new perspectives for understanding adolescent health.
血尿素氮（BUN）水平是评估肾功能和全身免疫炎症状态的常用指标之一。在青少年人群中，BUN 水平的变化可能与多种因素有关，包括生理性脱水、营养摄入、体力活动等生活方式的影响，以及可能的内分泌或代谢紊乱。近年来，越来越多的研究表明，BUN 水平不仅反映了肾脏功能，还可能与身体的炎症状态有关。全身免疫炎症指数（SII）是一个综合指数，考虑了血小板计数、中性粒细胞和淋巴细胞计数，被认为能有效反映身体的免疫状态和炎症反应。然而，SII 和 BUN 之间的关系在青少年人群中的研究还相对较少。本研究旨在探讨美国青少年人群中 SII 与 BUN 水平之间的关系，并进一步分析影响它们的因素。我们使用国家健康和营养调查（NHANES）数据库中的数据进行了一项横断面研究。通过描述性统计、相关分析和回归分析，我们探讨了 SII 和 BUN 水平之间的关系。我们发现 SII 和 BUN 水平之间存在显著的负相关，随着 SII 水平的升高，BUN 水平降低（以 BUN 为因变量，SII 为结果变量）。我们对这种关系进行了多元回归分析，控制了性别、年龄、种族和 BMI 等可能的混杂因素，发现这种负相关仍然显著。我们的研究结果揭示了 SII 和 BUN 水平之间的重要关系，并为了解青少年健康提供了新的视角。
