亚麻籽油可降低载脂蛋白 B100 仅 LDLrKO 小鼠的动脉粥样硬化。
Echium oil reduces atherosclerosis in apoB100-only LDLrKO mice.
机构信息
Department of Pathology/Section on Lipid Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, United States.
出版信息
Atherosclerosis. 2012 Jan;220(1):118-21. doi: 10.1016/j.atherosclerosis.2011.10.025. Epub 2011 Oct 29.
Abstract
INTRODUCTION
The anti-atherogenic and hypotriglyceridemic properties of fish oil are attributed to its enrichment in eicosapentaenoic acid (EPA; 20:5, n-3) and docosahexaenoic acid (DHA; 22:6, n-3). Echium oil contains stearidonic acid (SDA; 18:4, n-3), which is metabolized to EPA in humans and mice, resulting in decreased plasma triglycerides.
OBJECTIVE
We used apoB100 only, LDLrKO mice to investigate whether echium oil reduces atherosclerosis.
METHODS
Mice were fed palm, echium, or fish oil-containing diets for 16 weeks and plasma lipids, lipoproteins, and atherosclerosis were measured.
RESULTS
Compared to palm oil, echium oil feeding resulted in significantly less plasma triglyceride and cholesterol levels, and atherosclerosis, comparable to that of fish oil.
CONCLUSION
This is the first report that echium oil is anti-atherogenic, suggesting that it may be a botanical alternative to fish oil for atheroprotection.
摘要
简介
鱼油具有抗动脉粥样硬化和降甘油三酯的特性，这要归因于其富含二十碳五烯酸（EPA；20:5，n-3）和二十二碳六烯酸（DHA；22:6，n-3）。蓝蓟油含有二十碳四烯酸（SDA；18:4，n-3），在人体和小鼠中，SDA 可代谢为 EPA，从而降低血浆甘油三酯水平。
目的
我们使用仅载脂蛋白 B100（apoB100）缺陷型 LDL 受体敲除（LDLrKO）小鼠来研究蓝蓟油是否可以减少动脉粥样硬化。
方法
用棕榈油、蓝蓟油或鱼油喂养小鼠 16 周，并检测血浆脂质、脂蛋白和动脉粥样硬化情况。
结果
与棕榈油相比，蓝蓟油喂养导致血浆甘油三酯和胆固醇水平显著降低，动脉粥样硬化程度与鱼油相当。
结论
这是首个关于蓝蓟油具有抗动脉粥样硬化作用的报告，提示其可能是一种替代鱼油用于动脉粥样硬化保护的植物性选择。
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