Biostatistics and Epidemiology Service, The New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA.
Cancer Causes Control. 2012 Jan;23(1):153-64. doi: 10.1007/s10552-011-9864-y. Epub 2011 Nov 20.
To examine if survival has changed over the last 20 years in patients with base of tongue and tonsil cancers in the United States.
Using SEER data, we employed Kaplan-Meier method to draw survival curves and calculate survival rates, and estimated adjusted hazard ratios (HR).
From the 1980s to the 2000s, the 5-year overall survival rates statistically significantly improved by 100% from 25 to 51% among patients with one primary base of tongue cancer and 28-60% among those with one primary tonsil cancer (p values for trend <0.001). In addition, the 5-year cancer-specific survival improved by 222.4 and 276%, respectively, among two types of patients. Survival improvement was more pronounced among male patients than among female patients regardless of young or old age, while the improvement was generally consistent among patients with different tumor stages and treatment methods. In contrast, however, those patients with subsequent multiple cancers showed no improvement in overall survival over time.
The survival of patients with base of tongue and tonsil cancer has significantly improved over the last decades in the United States. Whether the improvement is associated with HPV infection, screening, or early detection is worthy to study in future.
研究美国舌根和扁桃体癌患者在过去 20 年中的生存率是否发生了变化。
我们利用 SEER 数据，采用 Kaplan-Meier 法绘制生存曲线并计算生存率，并估计调整后的风险比（HR）。
从 20 世纪 80 年代到 21 世纪 00 年代，对于单发舌根癌患者，5 年总生存率从 25%显著提高至 51%（趋势检验 p 值<0.001），对于单发扁桃体癌患者，5 年总生存率从 28%提高至 60%（趋势检验 p 值<0.001）。此外，两种类型患者的 5 年癌症特异性生存率分别提高了 222.4%和 276%。无论年龄大小、性别如何，生存率的提高在男性患者中比女性患者更为显著，而在不同肿瘤分期和治疗方法的患者中，生存率的提高基本一致。然而，与这些患者相反，那些随后患有多种癌症的患者在整体生存率方面并未随着时间的推移而改善。
在美国，过去几十年来，舌根和扁桃体癌患者的生存率有了显著提高。这种提高是否与 HPV 感染、筛查或早期检测有关，值得在未来的研究中探讨。
