Xu Zhongxin, Shan Ying
Indian J Biochem Biophys. 2014 Aug;51(4):321-5.
Portulaca oleracea L. has been used as a food and medicinal plant for thousands of years in China. Polysaccharides extracted from P. oleracea L. (POP) are its main bioactive compound and have multiple pharmacological activities. However, anti-fatigue effects of POP have not yet been tested. This study was designed to investigate the anti-fatigue effects of POP in mice using the rotarod and forced swimming tests. The mice were randomly divided into four groups, namely normal control group, low-dose POP supplementation group, medium-dose POP supplementation group and high-dose POP supplementation group. The normal control group received distilled water and the supplementation groups received different doses of POP (75, 150 and 300 mg/kg, respectively). The POP or distilled water was administered orally and daily for 30 day. After 30 days, the rotarod and forced swimming tests were performed and then several biochemical parameters related to fatigue were determined. The data showed that POP prolonged the riding times and exhaustive swimming times of mice, decreasing blood lactic acid and serum urea nitrogen levels, as well as increasing the liver and muscle glycogen contents. These results indicated that POP had the anti-fatigue effects.
马齿苋在中国已被用作食物和药用植物达数千年之久。从马齿苋中提取的多糖（POP）是其主要生物活性化合物，具有多种药理活性。然而，POP的抗疲劳作用尚未得到测试。本研究旨在通过转棒试验和强迫游泳试验研究POP对小鼠的抗疲劳作用。将小鼠随机分为四组，即正常对照组、低剂量POP补充组、中剂量POP补充组和高剂量POP补充组。正常对照组给予蒸馏水，补充组给予不同剂量的POP（分别为75、150和300 mg/kg）。POP或蒸馏水经口每日给药30天。30天后，进行转棒试验和强迫游泳试验，然后测定几个与疲劳相关的生化参数。数据显示，POP延长了小鼠的骑行时间和力竭游泳时间，降低了血乳酸和血清尿素氮水平，并增加了肝脏和肌肉糖原含量。这些结果表明，POP具有抗疲劳作用。
