Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Nat Struct Mol Biol. 2011 Nov 20;18(12):1424-7. doi: 10.1038/nsmb.2150.
Sudan virus (genus Ebolavirus) is lethal, yet no monoclonal antibody is known to neutralize it. We here describe antibody 16F6 that neutralizes Sudan virus and present its structure bound to the trimeric viral glycoprotein. Unexpectedly, the 16F6 epitope overlaps that of KZ52, the only other antibody against the GP(1,2) core to be visualized to date. Furthermore, both antibodies against this crucial epitope bridging GP1-GP2 neutralize at a post-internalization step--probably fusion.
苏丹病毒（埃博拉病毒属）是致命的，但目前还没有已知的单克隆抗体能够中和它。我们在这里描述了一种中和苏丹病毒的抗体 16F6，并展示了它与三聚体病毒糖蛋白结合的结构。出乎意料的是，16F6 表位与 KZ52 重叠，后者是迄今为止唯一可视化的针对 GP(1,2)核心的针对 GP(1,2)核心的抗体。此外，针对这个关键表位的这两种抗体在进入细胞内后都能中和——可能是融合。
