Hoffman I, Vos R, Tack J
Division of Pediatrics, Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium.
Neurogastroenterol Motil. 2009 May;21(5):517-20, e6. doi: 10.1111/j.1365-2982.2007.01057.x. Epub 2007 Dec 31.
In adults, a slow caloric drinking test has been proposed as a non-invasive tool to estimate gastric accommodation and to quantify meal-induced symptoms in functional dyspepsia (FD). The same test has been proposed for paediatric FD, but normal values are only available for adolescents and adults. The aim of the study was (i) to establish normal values for the satiety drinking test in young children and (ii) to study the influence of demographic factors. In all, 59 healthy children [27 girls; age range 5-16 years, body mass index (BMI) 17.4 +/- 2.5 kg m(-2)] were studied in the morning after an overnight fast. They drank a liquid nutrient meal (1.5 kcal mL(-1)) from beakers that were filled by a peristaltic pump filled at a rate of 15 mL min(-1) with. For every 5 min, satiety was scored on a graphic rating scale grade 0-5 (1 = threshold, 5 = maximum), until a score of 5 was reached. Values are given as mean +/- SEM and compared by t-test; correlation analysis was performed using Spearman rank test. All children performed the test as indicated except for one 5 years old who stopped prematurely for dislike of the taste. The endpoint was reached at 360 +/- 23 mL (540 +/- 34 kcal), and was age-dependent (Spearman r = 0.28, P = 0.03). No correlation was found between the maximum volume ingested and gender, weight, height or BMI. Age-dependent normal ranges were determined for ages 5-16 at 3-year intervals, and were found to increase with age. We established feasibility of and normal values for a non-invasive satiety drinking test in children with an age range of 5-15 years. This tool can now be used in the assessment of paediatric FD and eating disorders.
在成人中，慢热量饮水试验已被提议作为一种非侵入性工具，用于评估胃容纳功能并量化功能性消化不良（FD）患者进餐诱发的症状。同样的试验也被用于儿科FD，但仅青少年和成人有正常参考值。本研究的目的是：（i）确定幼儿饱腹感饮水试验的正常参考值；（ii）研究人口统计学因素的影响。总共59名健康儿童（27名女孩；年龄范围5 - 16岁，体重指数（BMI）17.4±2.5 kg/m²）在禁食过夜后的早晨进行了研究。他们从烧杯中饮用一种液体营养餐（1.5千卡/毫升），烧杯由蠕动泵以15毫升/分钟的速度填充。每5分钟，根据0 - 5级的图形评分量表对饱腹感进行评分（1 = 阈值，5 = 最大值），直至达到5分。数值以平均值±标准误表示，并通过t检验进行比较；使用Spearman秩相关检验进行相关分析。除了一名因不喜欢味道而提前停止试验的5岁儿童外，所有儿童均按要求完成了试验。终点摄入量为360±23毫升（540±34千卡），且与年龄相关（Spearman相关系数r = 0.28，P = 0.03）。摄入的最大量与性别、体重、身高或BMI之间未发现相关性。确定了5 - 16岁每隔3年的年龄相关正常范围，发现其随年龄增加。我们确定了年龄范围为5 - 15岁儿童非侵入性饱腹感饮水试验的可行性和正常参考值。该工具现在可用于儿科FD和饮食失调的评估。
