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[婴幼儿及青少年胆结石]

[Cholelithiasis in infants, children and adolescents].

作者信息

Debray Dominique, Franchi-Abella Stéphanie, Irtan Sabine, Girard Muriel

机构信息

AP-HP, CHU Necker-Enfants-Malades, pôle médicochirurgical, hépatologie pédiatrique, 75015 Paris, France.

出版信息

Presse Med. 2012 May;41(5):466-73. doi: 10.1016/j.lpm.2011.09.018. Epub 2011 Nov 21.

Abstract

The prevalence of cholelithiasis is estimated within 0.13% and 2% of children under 19 years of age. Pigment stones are the commonest type of gallstones in children, without recognizable predisposing factors in infants or secondary to a predisposing disease such as chronic hemolysis and ileal disease in children. In adolescents, idiopathic cholesterol gallstones accounts for the majority, such as in adults. Gallbladder stones are found in 80 to 90% of cases and common bile duct stones in 10 to 20% of cases. When common bile duct stones are found, a choledocal cyst with anomalous pancreatobiliary duct junction needs to be excluded. Magnetic resonance cholangiopancreatography should be performed in first line. Cholecystectomy is not indicated for silent gallstones, except in children with a predisposing disease such as chronic hemolysis. Treatment of common bile duct stones includes interventional radiologic, endoscopic or surgical procedures. Stone extraction may be performed at endoscopic retrograde cholangiopancreatography with or without sphincterotomy, combined with laparoscopic cholecystectomy. In children without a predisposing disease or no residual gallstones indicating a cholescystectomy, conservative management (percutaneous cholangiography with biliary drainage) may be proposed in specialised centers, especially for infants. A hepaticojejunostomy is indicated in cases of choledocal cyst with anomalous pancreatobiliary duct junctions.

摘要

据估计,19岁以下儿童胆石症的患病率在0.13%至2%之间。色素结石是儿童中最常见的胆结石类型,婴儿中无明显的诱发因素,儿童中也不是继发于慢性溶血和回肠疾病等诱发疾病。在青少年中,特发性胆固醇结石占大多数,与成人情况类似。80%至90%的病例存在胆囊结石,10%至20%的病例存在胆总管结石。当发现胆总管结石时,需要排除伴有胰胆管异常连接的胆总管囊肿。应首先进行磁共振胰胆管造影。对于无症状胆结石,除了患有慢性溶血等诱发疾病的儿童外,不建议进行胆囊切除术。胆总管结石治疗包括介入放射学、内镜或外科手术。可在内镜逆行胰胆管造影时进行结石取出,可进行或不进行括约肌切开术,并联合腹腔镜胆囊切除术。对于没有诱发疾病或没有提示胆囊切除术的残留胆结石儿童,在专业中心可采用保守治疗(经皮胆管造影及胆道引流),尤其适用于婴儿。对于伴有胰胆管异常连接的胆总管囊肿病例,需进行肝空肠吻合术。

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