Pathology Department, Ankara Child Diseases Hematology Oncology Research and Training Hospital, Ankara, Turkey.
World J Pediatr. 2013 Feb;9(1):25-31. doi: 10.1007/s12519-011-0323-3. Epub 2011 Nov 21.
This paper presents a detailed incidence study on childhood solid tumors comprising a histopathology-based documentation of benign and malignant lesions.
The Ankara Pediatric Pathology Working Group collected databases of pediatric solid tumors from six pediatric reference centers in order to analyze the incidence, distribution and some epidemiologic characteristics of the tumors and to establish a multicenter database for further studies. A five-year retrospective archive search was carried out. Excluding epithelial tumors of the skin, leukemia, lymphoreticular system neoplasias, metastatic tumors, and hamartomas, 1362 solid tumors in 1358 patients were classified according to age, sex, localization, histopathology and clinical behavior.
The male/female ratio was 0.9; 14.8% (201) of the patients belonged to 0-1 year age group, 20.7% (281) to 2-4 years, 25.9% (352) to 5-10 years, 22.2% (301) to 11-14 years, and 16.4% (223) to 15-18 years. Among all tumors, 708 (52.0%) were malignant, 645 (47.4%) benign tumors, 2 (0.1%) borderline tumors, and 2 (0.1%) unknown behavioral tumors. Malignant tumors were found in 50.2% (357) of female patients and in 54.0% (349) of male patients. A balanced distribution between benign and malignant entities among children under 18 years was observed. Comparison between the age groups revealed malignant cases outnumbered benign cases under 4 years of age while benign tumor numbers increased after 10 years of age. The most common entities in the malignant group were of sympathetic nervous system origin, while soft tissue tumors far outnumbered the others in the benign group.
We conclude that the cancer patterns of children in the Ankara region mostly resemble with those of the western population. This study provides useful information on the diagnosis of solid tumors in children and highlights variations in cancer incidence in different age groups.
本文详细研究了儿童实体瘤，包括基于组织病理学的良性和恶性病变的文献记载。
安卡拉儿科病理学工作组从六个儿科参考中心收集了小儿实体瘤数据库，以分析肿瘤的发病率、分布和一些流行病学特征，并建立一个多中心数据库进行进一步研究。进行了为期五年的回顾性档案搜索。排除皮肤上皮肿瘤、白血病、淋巴网状系统肿瘤、转移性肿瘤和错构瘤后，根据年龄、性别、部位、组织病理学和临床行为，将 1358 例患者的 1362 例实体瘤分为 14 组。
男/女比例为 0.9；14.8%（201 例）的患者年龄在 0-1 岁，20.7%（281 例）在 2-4 岁，25.9%（352 例）在 5-10 岁，22.2%（301 例）在 11-14 岁，16.4%（223 例）在 15-18 岁。在所有肿瘤中，708 例（52.0%）为恶性肿瘤，645 例（47.4%）为良性肿瘤，2 例（0.1%）为交界性肿瘤，2 例（0.1%）为行为未知肿瘤。女性患者中恶性肿瘤占 50.2%（357 例），男性患者中恶性肿瘤占 54.0%（349 例）。在 18 岁以下的儿童中，良性和恶性肿瘤之间的分布是平衡的。各年龄组比较显示，4 岁以下儿童恶性病例多于良性病例，10 岁以后良性肿瘤数量增加。恶性肿瘤组中最常见的实体瘤来源于交感神经系统，而良性肿瘤组中软组织肿瘤数量远远超过其他肿瘤。
我们得出的结论是，安卡拉地区儿童的癌症模式与西方人群大多相似。本研究为儿童实体瘤的诊断提供了有用的信息，并强调了不同年龄组癌症发病率的差异。
