Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.
Pediatr Blood Cancer. 2012 Apr;58(4):633-5. doi: 10.1002/pbc.23371. Epub 2011 Nov 21.
Children with Down syndrome (DS) bear an increased risk of acute lymphoblastic leukemia (ALL) and treatment complications. We compared blood counts and toxicities in 22 DS and 44 non-DS ALL patients. Patients with DS had deeper, longer neutrophil and monocyte count nadirs; more toxicities (HR 2.0, P = 0.0005); longer hospitalizations (HR 1.4, P < 0.0001); and more frequent microbiologically documented infections (HR 5.7, P = 0.0019), mucositis (HR 29.0, P = 0.0006), and cellulitis (HR 3.0, P = 0.033). Severe neutropenia, monocytopenia, and increased cellulitis in DS-ALL suggest the importance of skin hygiene, vigilance and aggressive treatment of cutaneous infections.
唐氏综合征（DS）患儿患急性淋巴细胞白血病（ALL）及治疗相关并发症的风险增加。我们比较了 22 例 DS 患儿和 44 例非 DS ALL 患儿的血象和毒性反应。DS 患儿的中性粒细胞和单核细胞计数最低值更深、更低；毒性反应更多（HR 2.0，P=0.0005）；住院时间更长（HR 1.4，P<0.0001）；更频繁地发生微生物学证实的感染（HR 5.7，P=0.0019）、黏膜炎（HR 29.0，P=0.0006）和蜂窝织炎（HR 3.0，P=0.033）。DS-ALL 患儿中严重中性粒细胞减少症、单核细胞减少症和蜂窝织炎发生率增加表明皮肤卫生、警惕性和积极治疗皮肤感染非常重要。
