Raedler A, Reinecker C
Universitätskrankenhaus Eppendorf, Medizinische Kern- und Poliklinik, Hamburg.
Immun Infekt. 1990 Aug;18(4):121-6.
The therapy of inflammatory bowel diseases (Crohn's disease, ulcerative colitis) has been improved in recent years. This is mainly due to our better understanding of application of aminosalicylates and steroids in regard to localization, activity, and type of chronic inflammatory bowel disease. Newly developed aminosalicylates like mesalazine provoke less side effects. Furthermore, they seem to be effective in the treatment of ileal inflammation of Crohn's disease. Therapy with immunosuppressive drugs like mercaptopurine, azathioprine, and cyclosporin A is justified in case of steroid-resistant Crohn's disease. Alternative therapeutic concepts are at present at the stage of clinical trial.
近年来，炎症性肠病（克罗恩病、溃疡性结肠炎）的治疗有了改善。这主要是因为我们对氨基水杨酸酯类和类固醇在慢性炎症性肠病的定位、活性及类型方面的应用有了更好的理解。新研发的氨基水杨酸酯类如美沙拉嗪产生的副作用较少。此外，它们似乎对克罗恩病的回肠炎症治疗有效。对于类固醇抵抗的克罗恩病，使用巯嘌呤、硫唑嘌呤和环孢素A等免疫抑制药物进行治疗是合理的。目前，替代治疗概念正处于临床试验阶段。
