小鼠中针对单纯疱疹病毒的MHC II类限制性细胞毒性T淋巴细胞的证明。
Demonstration of MHC class II-restricted cytotoxic T lymphocytes in mice against herpes simplex virus.
作者信息
Kolaitis G, Doymaz M, Rouse B T
机构信息
Department of Microbiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37996-0845.
出版信息
Immunology. 1990 Sep;71(1):101-6.
Abstract
In humans CD4+ major histocompatibility complex (MHC) class II-restricted T cells dominate cytotoxic T-lymphocyte (CTL) responses to herpes simplex virus (HSV), whereas in the mouse only CD8+ MHC class I-restricted CTL have been reported. In this study, we demonstrate that a minor fraction (around 30%) of the response in draining lymph nodes of acute local HSV infections is attributable to CD4+ CTL mice. Such CTL were identified on the basis of antiserum inhibition studies, negative depletion approaches, as well as their differing antigen processing requirements to CD8+ MHC class I-restricted CTL. A possible role for CD4+ CTL as immunoregulators in local infections is discussed briefly.
摘要
在人类中，CD4⁺主要组织相容性复合体（MHC）II类限制性T细胞主导对单纯疱疹病毒（HSV）的细胞毒性T淋巴细胞（CTL）应答，而在小鼠中，据报道只有CD8⁺MHC I类限制性CTL参与应答。在本研究中，我们证明，急性局部HSV感染引流淋巴结中一小部分（约30%）的应答归因于CD4⁺CTL小鼠。此类CTL是根据抗血清抑制研究、阴性清除方法以及它们与CD8⁺MHC I类限制性CTL不同的抗原处理要求来鉴定的。本文简要讨论了CD4⁺CTL作为局部感染免疫调节因子的可能作用。
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