• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

母鼠分离对创伤后应激障碍动物模型的持久影响:对记忆和海马氧化应激的影响。

Long-lasting effects of maternal separation on an animal model of post-traumatic stress disorder: effects on memory and hippocampal oxidative stress.

机构信息

Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, Porto Alegre RS 90035-003, Brazil.

出版信息

Neurochem Res. 2012 Apr;37(4):700-7. doi: 10.1007/s11064-011-0660-6. Epub 2011 Nov 23.

DOI:10.1007/s11064-011-0660-6
PMID:22108759
Abstract

Adverse early life events, such as periodic maternal separation, may alter the normal pattern of brain development and subsequently the vulnerability to a variety of mental disorders in adulthood. Patients with a history of early adversities show higher frequency of post-traumatic stress disorder (PTSD). This study was undertaken to verify if repeated long-term separation of pups from dams would affect memory and oxidative stress parameters after exposure to an animal model of PTSD. Nests of Wistar rats were divided into intact and subjected to maternal separation (incubator at 32°C, 3 h/day) during post-natal days 1-10. When adults, the animals were subdivided into exposed or not to a PTSD model consisting of exposure to inescapable footshock, followed by situational reminders. One month after exposure to the shock, the animals were exposed to a memory task (Morris water maze) and another month later animals were sacrificed and DNA breaks and antioxidant enzymes activities were measured in the hippocampus. Rats exposed to shock or maternal separation plus shock showed long-lasting effects on spatial memory, spending more time in the opposite quadrant of the water maze. This effect was higher in animals subjected to both maternal separation and shock. Both shock and maternal separation induced a higher score of DNA breaks in the hippocampus. No differences were observed on antioxidant enzymes activities. In conclusion, periodic maternal separation may increase the susceptibility to the effects of a stressor applied in adulthood on performance in the water maze. Increased DNA breaks in hippocampus was induced by both, maternal separation and exposure to shock.

摘要

不良的早期生活事件,如周期性的母婴分离,可能会改变大脑发育的正常模式,并随后导致成年后易患各种精神障碍。有早期逆境史的患者表现出更高频率的创伤后应激障碍(PTSD)。本研究旨在验证长期周期性母婴分离是否会影响 PTSD 动物模型暴露后记忆和氧化应激参数。Wistar 大鼠的巢分为完整组和经历母婴分离组(在出生后第 1-10 天置于 32°C 的孵化器中,每天 3 小时)。当大鼠成年后,将它们分为经历或不经历 PTSD 模型暴露组,即不可逃避的足底电击暴露,随后是情境提示。在电击暴露后 1 个月,动物进行记忆任务(Morris 水迷宫),1 个月后处死动物,并测量海马体中的 DNA 断裂和抗氧化酶活性。经历电击或母婴分离加电击的大鼠表现出空间记忆的持久影响,在水迷宫的相反象限花费更多时间。这种影响在同时经历母婴分离和电击的动物中更高。电击和母婴分离均在海马体中诱导更高的 DNA 断裂评分。抗氧化酶活性没有差异。总之,周期性母婴分离可能会增加成年后应激源对水迷宫表现的影响易感性。海马体中的 DNA 断裂是由母婴分离和暴露于电击共同引起的。

相似文献

1
Long-lasting effects of maternal separation on an animal model of post-traumatic stress disorder: effects on memory and hippocampal oxidative stress.母鼠分离对创伤后应激障碍动物模型的持久影响:对记忆和海马氧化应激的影响。
Neurochem Res. 2012 Apr;37(4):700-7. doi: 10.1007/s11064-011-0660-6. Epub 2011 Nov 23.
2
Long lasting sex-specific effects upon behavior and S100b levels after maternal separation and exposure to a model of post-traumatic stress disorder in rats.母体分离及暴露于大鼠创伤后应激障碍模型后,对行为和S100b水平产生的长期性别特异性影响。
Brain Res. 2007 May 4;1144:107-16. doi: 10.1016/j.brainres.2007.01.084. Epub 2007 Jan 30.
3
Maternal Separation-Induced Histone Acetylation Correlates with BDNF-Programmed Synaptic Changes in an Animal Model of PTSD with Sex Differences.母婴分离诱导的组蛋白乙酰化与 PTSD 动物模型中性别差异相关的 BDNF 编程的突触变化相关。
Mol Neurobiol. 2021 Apr;58(4):1738-1754. doi: 10.1007/s12035-020-02224-6. Epub 2020 Nov 27.
4
Vitamin C attenuates memory loss induced by post-traumatic stress like behavior in a rat model.维生素 C 可减轻创伤后应激样行为引起的大鼠记忆丧失。
Behav Brain Res. 2020 Feb 3;379:112350. doi: 10.1016/j.bbr.2019.112350. Epub 2019 Nov 8.
5
Female-dependent impaired fear memory of adult rats induced by maternal separation, and screening of possible related genes in the hippocampal CA1.母婴分离诱导成年大鼠出现雌性依赖的恐惧记忆受损,并对海马CA1区可能相关基因进行筛选。
Behav Brain Res. 2014 Jul 1;267:111-8. doi: 10.1016/j.bbr.2014.03.022. Epub 2014 Mar 22.
6
Maternal Deprivation Enhances Contextual Fear Memory via Epigenetically Programming Second-Hit Stress-Induced Reelin Expression in Adult Rats.母体剥夺通过表观遗传编程第二击应激诱导的成年大鼠 reelin 表达增强情境恐惧记忆。
Int J Neuropsychopharmacol. 2018 Nov 1;21(11):1037-1048. doi: 10.1093/ijnp/pyy078.
7
Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures.母婴分离应激会加剧反复癫痫发作的幼鼠的认知缺陷。
Epilepsia. 2002 Oct;43(10):1141-8. doi: 10.1046/j.1528-1157.2002.14602.x.
8
Vitamin E prevents the cognitive impairments in post-traumatic stress disorder rat model: behavioral and molecular study.维生素 E 可预防创伤后应激障碍大鼠模型的认知障碍:行为和分子研究。
Psychopharmacology (Berl). 2020 Feb;237(2):599-607. doi: 10.1007/s00213-019-05395-w. Epub 2019 Nov 16.
9
Amelioration of oxidative stress-induced phenotype loss of parvalbumin interneurons might contribute to the beneficial effects of environmental enrichment in a rat model of post-traumatic stress disorder.改善氧化应激诱导的小白蛋白中间神经元表型丧失可能有助于环境富集对创伤后应激障碍大鼠模型产生有益影响。
Behav Brain Res. 2016 Oct 1;312:84-92. doi: 10.1016/j.bbr.2016.06.016. Epub 2016 Jun 11.
10
Behavioral effects of early life maternal trauma witness in rats.大鼠早期生活中母亲创伤目击的行为影响。
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:80-87. doi: 10.1016/j.pnpbp.2017.10.013. Epub 2017 Oct 24.

引用本文的文献

1
Dissociative symptoms in school-aged adopted children who experienced maternal separation and disruptive caregiving in infancy.在婴儿期经历过母婴分离和照料中断的学龄期领养儿童中的分离症状。
Front Psychiatry. 2025 Apr 17;16:1453950. doi: 10.3389/fpsyt.2025.1453950. eCollection 2025.
2
Maternal Separation Exhibits a Sex Dimorphism in Memory Impairments in Adolescent Rats: Acute Methylphenidate Administration as a Treatment.母体分离在青春期大鼠记忆损伤中表现出性别差异:急性给予哌甲酯作为一种治疗方法。
Birth Defects Res. 2025 Feb;117(2):e2441. doi: 10.1002/bdr2.2441.
3
Chronic stress induces Alzheimer's disease-like pathologies through DNA damage-Chk1-CIP2A signaling.

本文引用的文献

1
A three-year follow-up study of the psychosocial predictors of delayed and unresolved post-traumatic stress disorder in Taiwan Chi-Chi earthquake survivors.台湾集集地震幸存者创伤后应激障碍延迟和未解决的社会心理预测因素的三年随访研究。
Psychiatry Clin Neurosci. 2010 Jun;64(3):239-48. doi: 10.1111/j.1440-1819.2010.02087.x.
2
Impact of the hypothalamic-pituitary-adrenal/gonadal axes on trajectory of age-related cognitive decline.下丘脑-垂体-性腺轴对与年龄相关的认知衰退轨迹的影响。
Prog Brain Res. 2010;182:31-76. doi: 10.1016/S0079-6123(10)82002-3.
3
Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood.
慢性应激通过 DNA 损伤-Chk1-CIP2A 信号通路诱导阿尔茨海默病样病变。
Aging (Albany NY). 2024 May 30;16(10):9168-9187. doi: 10.18632/aging.205862.
4
Anethole as a promising antidepressant for maternal separation stress in mice by modulating oxidative stress and nitrite imbalance.茴芹作为一种有前途的抗抑郁药,可通过调节氧化应激和亚硝酸盐失衡来缓解母婴分离应激的小鼠。
Sci Rep. 2024 Apr 2;14(1):7766. doi: 10.1038/s41598-024-57959-2.
5
Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies.理解氧化应激、神经炎症和异常髓鞘形成在与抑郁相关的过度攻击中的作用:来自机制研究的最新见解。
Int J Mol Sci. 2023 Jan 4;24(2):915. doi: 10.3390/ijms24020915.
6
Behavioral effects of environmental enrichment on male and female wistar rats with early life stress experiences.环境富集对有早期生活应激经历的雄性和雌性Wistar大鼠的行为影响。
Front Physiol. 2022 Sep 26;13:837661. doi: 10.3389/fphys.2022.837661. eCollection 2022.
7
Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis.不同早期生活应激啮齿动物模型中海马体依赖性记忆的缺陷:系统评价与荟萃分析。
Transl Psychiatry. 2021 Apr 20;11(1):231. doi: 10.1038/s41398-021-01352-4.
8
Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processes.不同大鼠脑区的蛋白质组学分析揭示了长期母婴分离对细胞死亡相关过程中涉及的蛋白质的调节作用。
Biol Res. 2021 Feb 8;54(1):4. doi: 10.1186/s40659-021-00327-5.
9
Maternal Separation-Induced Histone Acetylation Correlates with BDNF-Programmed Synaptic Changes in an Animal Model of PTSD with Sex Differences.母婴分离诱导的组蛋白乙酰化与 PTSD 动物模型中性别差异相关的 BDNF 编程的突触变化相关。
Mol Neurobiol. 2021 Apr;58(4):1738-1754. doi: 10.1007/s12035-020-02224-6. Epub 2020 Nov 27.
10
Behavioral and Oxidative Stress Changes in Mice Subjected to Combinations of Multiple Stressors Relevant to Irritable Bowel Syndrome.遭受与肠易激综合征相关的多种应激源组合的小鼠的行为和氧化应激变化
Brain Sci. 2020 Nov 17;10(11):865. doi: 10.3390/brainsci10110865.
新生期母婴分离会影响成年期中枢促肾上腺皮质素释放因子受体的应激反应性。
Psychopharmacology (Berl). 2011 Mar;214(1):221-9. doi: 10.1007/s00213-010-1885-9. Epub 2010 May 25.
4
Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory.应激反应招募海马内源性大麻素系统来调节恐惧记忆。
Learn Mem. 2010 Mar 26;17(4):202-9. doi: 10.1101/lm.1721010. Print 2010 Apr.
5
Anti-glucocorticoid gene therapy reverses the impairing effects of elevated corticosterone on spatial memory, hippocampal neuronal excitability, and synaptic plasticity.抗糖皮质激素基因治疗可逆转皮质酮升高对空间记忆、海马神经元兴奋性和突触可塑性的损害作用。
J Neurosci. 2010 Feb 3;30(5):1712-20. doi: 10.1523/JNEUROSCI.4402-09.2010.
6
Hippocampal-related memory deficits and histological damage induced by neonatal ionizing radiation exposure. Role of oxidative status.新生期电离辐射暴露致海马相关记忆损伤和组织学损害及其氧化应激状态的作用
Brain Res. 2010 Feb 2;1312:67-78. doi: 10.1016/j.brainres.2009.11.053. Epub 2009 Nov 27.
7
Environmental and tactile stimulation modulates the neonatal handling effect on adult rat spatial memory.环境和触觉刺激调节新生期处理对成年大鼠空间记忆的影响。
Int J Dev Neurosci. 2009 Dec;27(8):747-55. doi: 10.1016/j.ijdevneu.2009.08.013. Epub 2009 Aug 29.
8
Sex-specific differences on caffeine consumption and chronic stress-induced anxiety-like behavior and DNA breaks in the hippocampus.咖啡因摄入、慢性应激诱导的焦虑样行为以及海马体DNA断裂方面的性别特异性差异。
Pharmacol Biochem Behav. 2009 Nov;94(1):63-9. doi: 10.1016/j.pbb.2009.07.007. Epub 2009 Jul 25.
9
Chronic hyperhomocysteinemia alters antioxidant defenses and increases DNA damage in brain and blood of rats: protective effect of folic acid.慢性高同型半胱氨酸血症改变大鼠脑和血液中的抗氧化防御并增加DNA损伤:叶酸的保护作用。
Neurochem Int. 2009 Jan;54(1):7-13. doi: 10.1016/j.neuint.2008.08.011. Epub 2008 Oct 14.
10
DNA strand breaks, neurodegeneration and aging in the brain.大脑中的DNA链断裂、神经退行性变与衰老
Mech Ageing Dev. 2008 Jul-Aug;129(7-8):483-91. doi: 10.1016/j.mad.2008.03.008. Epub 2008 Mar 25.