Institute of Biomolecular Chemistry, CNR-National Research Council of Italy, Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy.
Microb Ecol. 2012 Apr;63(3):490-5. doi: 10.1007/s00248-011-9980-y. Epub 2011 Nov 23.
The generic term "quorum sensing" has been adopted to describe the bacterial cell-to-cell communication mechanism which coordinates gene expression when the population has reached a high cell density. Quorum sensing depends on the synthesis of small molecules that diffuse in and out of bacterial cells. There are few reports about this mechanism in Archaea. We report the isolation and chemical characterization of small molecules belonging to class of diketopiperazines (DKPs) in Haloterrigena hispanica, an extremely halophilic archaeon. One of the DKPs isolated, the compound cyclo-(L-prolyl-L-valine) activated N-acyl homoserine lactone (AHL) bioreporters, indicating that Archaea may have the ability to interact with AHL-producing bacteria within mixed communities.
通用术语“群体感应”已被用于描述细菌细胞间的通讯机制，当种群达到高细胞密度时，该机制协调基因表达。群体感应依赖于扩散进出细菌细胞的小分子的合成。关于古菌中的这种机制，报道较少。我们报告了极端嗜盐古菌盐沼盐杆菌中小二酮哌嗪 (DKP) 类小分子的分离和化学特性。分离出的一种 DKP，即化合物环-(L-脯氨酰-L-缬氨酸)，激活了 N-酰基高丝氨酸内酯 (AHL) 生物报告物，表明古菌可能具有在混合群落中与产生 AHL 的细菌相互作用的能力。
