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仙人掌果实中分离得到的山奈酚和槲皮素具有抗抑郁作用。

Antidepressant-like Effect of Kaempferol and Quercitirin, Isolated from Opuntia ficus-indica var. saboten.

机构信息

Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University, Chuncheon 200-702, Korea.

出版信息

Exp Neurobiol. 2010 Jun;19(1):30-8. doi: 10.5607/en.2010.19.1.30. Epub 2010 Jun 30.

DOI:10.5607/en.2010.19.1.30
PMID:22110339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3214795/
Abstract

Opuntia ficus-indica var. saboten. is widely cultivated in Jeju Island (South Korea) for use in manufacture of health foods. This study described antidepressant effect of two flavonoids (kaempferol and quercitrin) isolated from the Opuntia ficus-indica var. saboten. The expression of the hypothalamic POMC mRNA or plasma β-endorphin levels were increased by extract of Opuntia ficus-indica var. saboten or its flavoniods administered orally. In addition, antidepressant activity was studied using tail suspension test (TST), forced swimming test (FST) and rota-rod test in chronically restraint immobilization stress group in mice. After restraint stress (2 hrs/day for 14 days), animals were kept in cage for 14 days without any further stress, bet with drugs. Mice were fed with a diet supplemented for 14 days and during the behavioral test period with kaempferol or quercitrin (30 mg/kg/day). POMC mRNA or plasma β-endorphin level was increased by extract of Opuntia ficus-indica var. saboten and its flavoniods. In addition, immobility time in TST and FST was significantly reduced by kaempferol or quercitrin. In rota-rod test, the time of permanence was maintained to the semblance of control group in turning at 15 rpm. Our results suggest that two flavonoids (kaempferol and quercitrin) isolated from the Opuntia ficus-indica var. saboten. show a potent antidepressant effect.

摘要

仙人掌果实 saboten. 在济州岛（韩国）广泛种植，用于制造保健食品。本研究描述了从仙人掌果实 saboten 中分离出的两种类黄酮（山奈酚和槲皮素）的抗抑郁作用。仙人掌果实 saboten 或其类黄酮口服给药后，下丘脑 POMC mRNA 的表达或血浆 β-内啡肽水平增加。此外，还使用慢性束缚应激组小鼠的悬尾试验（TST）、强迫游泳试验（FST）和转棒试验研究了抗抑郁活性。在束缚应激（每天 2 小时，持续 14 天）后，动物在没有进一步应激的情况下在笼子中饲养 14 天，并给予药物。小鼠在补充饲料 14 天后进行饮食，在行为测试期间每天给予 30mg/kg 的山奈酚或槲皮素。仙人掌果实 saboten 及其类黄酮可增加 POMC mRNA 或血浆 β-内啡肽水平。此外，山奈酚或槲皮素可显著减少 TST 和 FST 中的不动时间。在转棒试验中，以 15rpm 的速度保持在对照组的相似位置。我们的结果表明，从仙人掌果实 saboten 中分离出的两种类黄酮（山奈酚和槲皮素）具有很强的抗抑郁作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7687/3214795/777c110512e2/en-19-30-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7687/3214795/7a2222ba0138/en-19-30-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7687/3214795/8a952b97772a/en-19-30-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7687/3214795/913af867e45b/en-19-30-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7687/3214795/777c110512e2/en-19-30-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7687/3214795/7a2222ba0138/en-19-30-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7687/3214795/8a952b97772a/en-19-30-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7687/3214795/913af867e45b/en-19-30-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7687/3214795/777c110512e2/en-19-30-g004.jpg

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J Ethnopharmacol. 2006 Jun 15;106(1):76-81. doi: 10.1016/j.jep.2005.12.004. Epub 2006 Jan 18.
3
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Life (Basel). 2024 Oct 21;14(10):1342. doi: 10.3390/life14101342.
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Molecules. 2024 Apr 26;29(9):2007. doi: 10.3390/molecules29092007.
5
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6
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7
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8
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5
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J Mol Neurosci. 2002 Feb-Apr;18(1-2):143-9. doi: 10.1385/JMN:18:1-2:143.
9
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10
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J Ethnopharmacol. 2001 Jun;76(1):1-9. doi: 10.1016/s0378-8741(01)00196-9.