Mora S, Millán R, Lungenstrass H, Díaz-Véliz G, Morán J A, Herrera-Ruiz M, Tortoriello J
Laboratorio de Farmacología del Comportamiento, Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Chile.
J Ethnopharmacol. 2006 Jun 15;106(1):76-81. doi: 10.1016/j.jep.2005.12.004. Epub 2006 Jan 18.
Behavioral effects of a hydroalcoholic (60% ethanol) extract from the leaves of Salvia elegans Vahl (Lamiaceae) were studied in male Sprague-Dawley rats. The extract was administered intraperitoneally and its effects on spontaneous motor activity (total motility, locomotion, rearing and grooming behavior) were monitored. Putative anxiolytic and antidepressant properties of Salvia elegans were studied in the elevated plus-maze test (EPM) and in the forced swimming test (FST), respectively. Deleterious effects of Salvia elegans on learning and memory were also studied by using active and passive avoidance paradigms. The results revealed that all doses (3.12, 12.5, 25 and 50 mg/kg) of the extract caused a significant decrease in total motility, locomotion, rearing and grooming behavior. Only the dose of 12.5 mg/kg increased the exploration of the EPM open arms in a similar way to that of diazepam (1 mg/kg). In the FST, all doses of the extract induced a reduction of immobility, in a similar way to that of fluoxetine (10 mg/kg) and imipramine (12.5 mg/kg), along with a significant increase in the time spent in swimming behavior. Acquisition of active avoidance responses was disrupted by pre-treatment with the extract, but retention of a passive avoidance response was not significantly modified. These results suggest that some of the components of the hydroalcoholic extract of Salvia elegans have psychotropic properties, which deserve further investigation.
研究了来自鼠尾草（唇形科）叶片的水醇提取物（60%乙醇）对雄性Sprague-Dawley大鼠的行为影响。提取物通过腹腔注射给药，并监测其对自发运动活动（总运动、移动、竖毛和理毛行为）的影响。分别在高架十字迷宫试验（EPM）和强迫游泳试验（FST）中研究了鼠尾草假定的抗焦虑和抗抑郁特性。还通过主动和被动回避范式研究了鼠尾草对学习和记忆的有害影响。结果显示，提取物的所有剂量（3.12、12.5、25和50 mg/kg）均导致总运动、移动、竖毛和理毛行为显著减少。只有12.5 mg/kg的剂量以与地西泮（1 mg/kg）相似的方式增加了对EPM开放臂的探索。在FST中，提取物的所有剂量均诱导不动时间减少，与氟西汀（10 mg/kg）和丙咪嗪（12.5 mg/kg）相似，同时游泳行为的时间显著增加。提取物预处理会干扰主动回避反应的获得，但被动回避反应的保持没有显著改变。这些结果表明，鼠尾草水醇提取物的某些成分具有精神活性特性，值得进一步研究。
