Wakusawa Chihiro, Fujimura Taku, Hashimoto Akira, Aiba Setsuya
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Case Rep Dermatol. 2011 Sep;3(3):219-22. doi: 10.1159/000333206. Epub 2011 Sep 30.
Myeloid sarcoma, which sometimes accompanies recurrent systemic leukemia, is a rare manifestation of congenital leukemia. We describe the case of a 1-month-old Japanese girl with myeloid sarcoma, who did not fulfill the criteria of systemic leukemia. The physical examination revealed a bruise-like plaque on the right side of her chest. Histopathologically, there were CD4+ CD56- CD68+ atypical large lymphocytes densely infiltrating the upper dermis and the subcutaneous tissue. Biopsy specimens from bone marrow contained only 3.4% of blast cells, showing an abnormality of the mixed-lineage leukemia gene. The skin lesions disappeared 10 days after chemotherapy, and there was no recurrence for one and a half years.
髓系肉瘤有时伴随复发性全身性白血病，是先天性白血病的一种罕见表现。我们报告一例1个月大的日本女孩患髓系肉瘤的病例，她不符合全身性白血病的标准。体格检查发现其胸部右侧有一个瘀斑样斑块。组织病理学检查显示，CD4+ CD56- CD68+非典型大淋巴细胞密集浸润上真皮层和皮下组织。骨髓活检标本中仅含有3.4%的原始细胞，显示混合谱系白血病基因异常。化疗10天后皮肤病变消失，并且在一年半的时间里没有复发。
