Goh Bee See, Tang Chian Ling, Tan Geok Chin
1Department of Otorhinolaryngology-Head and Neck Surgery, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Wilayah Persekutuan Kuala Lumpur, Malaysia.
2Institute of Ear, Hearing and Speech (Institute-HEARS), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 2):1023-1026. doi: 10.1007/s12070-015-0930-8. Epub 2015 Dec 12.
Myeloid sarcoma is a rare malignant extramedullary neoplasm of myeloid precursor cells. This disorder may occur in concomitance with or precede development of acute or chronic myeloid leukemia. Sometimes, it is the initial manifestation of relapse in a previously treated acute myeloid leukemia. We report a case of 11 years old boy with acute myeloid leukemia in remission state, presented with short history of right otalgia associated with facial nerve palsy. Diagnosis of right acute mastoiditis with facial nerve palsy as complication of acute otitis media was made initially. Patient underwent simple cortical mastoidectomy but histopathology from soft tissue that was sent revealed diagnosis of myeloid sarcoma. A leukemic relapse was confirmed by paediatric oncologist through bone marrow biopsy. Chemotherapy was commenced but patient responded poorly to the treatment.
髓系肉瘤是一种罕见的髓系前体细胞恶性髓外肿瘤。这种疾病可能与急性或慢性髓系白血病同时发生或在其发生之前出现。有时,它是既往治疗过的急性髓系白血病复发的初始表现。我们报告一例11岁处于缓解期的急性髓系白血病男孩,有短期右耳痛伴面神经麻痹病史。最初诊断为右急性乳突炎伴面神经麻痹,为急性中耳炎的并发症。患者接受了单纯皮质乳突切除术,但送检软组织的组织病理学检查显示为髓系肉瘤。儿科肿瘤学家通过骨髓活检证实白血病复发。开始化疗,但患者对治疗反应不佳。