根治性前列腺切除术后生化复发的预后因素
Prognostic factors for the development of biochemical recurrence after radical prostatectomy.
作者信息
Kotb Ahmed F, Elabbady Ahmed A
机构信息
Urology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
出版信息
Prostate Cancer. 2011;2011:485189. doi: 10.1155/2011/485189. Epub 2011 Jun 15.
Abstract
Prostate cancer is one of the most common cancers in Western countries and is associated with a considerable risk of mortality. Biochemical recurrence following radical prostatectomy is a relatively common finding, affecting approximately 25% of cases. The aim of our paper was to identify factors that can predict the occurrence of biochemical recurrence, so the patient can be properly counselled pre- and postoperatively. Medline review of the literatures was done followed by a group discussion on the chosen publications and their valuable influence. Preoperative serum total PSA and clinical stage, together with prostatectomy Gleason grade, tumour volume, and perineural and vascular invasions, were the most important variables found to influence outcome.
摘要
前列腺癌是西方国家最常见的癌症之一，且具有相当高的死亡风险。根治性前列腺切除术后的生化复发是一个相对常见的现象，约25%的病例会出现这种情况。我们这篇论文的目的是确定能够预测生化复发发生的因素，以便在术前和术后对患者进行适当的咨询。我们先对医学文献数据库进行了文献综述，随后针对所选出版物及其重要影响进行了小组讨论。术前血清总前列腺特异抗原（PSA）、临床分期，以及前列腺切除标本的 Gleason分级、肿瘤体积、神经周围和血管侵犯，是发现的影响预后的最重要变量。
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