Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Langmuir. 2012 Jan 10;28(1):757-65. doi: 10.1021/la2027016. Epub 2011 Dec 12.
Microstructures of sodium deoxycholate hydrogels were altered considerably in the presence of variable tris(hydroxymethyl)aminomethane (TRIS) concentrations. These observations were confirmed by use of X-ray diffraction, polarized optical microscopy, rheology, and differential scanning calorimetry measurements. Our studies reveal enhanced gel crystallinity and rigidity with increasing TRIS concentrations. The tunable hydrogel microstructures obtained under various conditions have been successfully utilized as templates to synthesize cyanine-based fluorescent nanoGUMBOS (nanoparticles from a group of uniform materials based on organic salts). A systematic variation in size (70-200 nm), with relatively low polydispersity and tunable spectral properties of [HMT][AOT] nanoGUMBOS, was achieved by use of these modified hydrogels. The gel microstructures are observed to direct the size as well as molecular self-assembly of the nanomaterials, thereby tuning their spectral properties. These modified hydrogels were also found to possess other interesting properties such as variable morphologies ranging from fibrous to spherulitic, variable degrees of crystallinity, rigidity, optical activity, and release profiles which can be exploited for a multitude of applications. Hence, this study demonstrates a novel method for modification of sodium deoxycholate hydrogels, their applications as templates for nanomaterials synthesis, as well as their potential applications in biotechnology and drug delivery.
去氧胆酸钠水凝胶的微观结构在三羟甲基氨基甲烷（TRIS）浓度变化的情况下发生了很大的变化。这些观察结果通过 X 射线衍射、偏光显微镜、流变学和差示扫描量热法测量得到了证实。我们的研究表明，随着 TRIS 浓度的增加，凝胶结晶度和刚性得到增强。在各种条件下获得的可调谐水凝胶微观结构已成功用作模板来合成基于菁染料的荧光纳米 GUMBOS（基于有机盐的一组均匀材料的纳米粒子）。通过使用这些改性水凝胶，实现了 [HMT][AOT] 纳米 GUMBOS 的尺寸（70-200nm）的系统变化，具有相对较低的多分散性和可调谐的光谱性质。凝胶微观结构被观察到可以控制纳米材料的尺寸和分子自组装，从而调节它们的光谱性质。还发现这些改性水凝胶具有其他有趣的性质，例如从纤维状到球晶状的可变形态、不同程度的结晶度、刚性、光学活性和释放曲线，这些性质可以用于多种应用。因此，本研究展示了一种修饰去氧胆酸钠水凝胶的新方法，以及它们作为纳米材料合成模板的应用，以及它们在生物技术和药物输送中的潜在应用。
