Liu Yongjun, Liu Xiaojie, Liu Chang, Zhang Wenan, Shi Ting, Liu Guanying
The Second Department of Spine Surgery, Yantaishan Hospital, Yantai, People's Republic of China.
Department of Plastic Surgery, Yantaishan Hospital, Yantai, People's Republic of China.
J Mater Sci Mater Med. 2025 Jan 15;36(1):11. doi: 10.1007/s10856-024-06850-7.
Diseases and injuries can cause significant bone loss, leading to increased medical expenses, decreased work efficiency, and a decline in quality of life. Bone tissue engineering (BTE) is gaining attention as an alternative to autologous and allogeneic transplantation due to the limited availability of donors. Biomaterials represent a promising strategy for bone regeneration, and their design should consider the three key processes in bone tissue engineering: osteogenesis, bone conduction, and bone induction. Certain bile acids (BAs) demonstrate significant antioxidant, anti-inflammatory, and immunosuppressive properties, and effectively promote bone and tissue regeneration. Additionally, the combination of BA molecule with other biological materials can help overcome problems associated with limited local bone regeneration and maintain a defined release state for a long time. Thus in this review, we focus on the role and the mechanism of bile acids in bone healing under different conditions, highlighting their unique properties and applications in gel fabrication, microencapsulation, and nanotechnology. These advancements serve as a basis for the advancement of biomaterials derived from BAs, specifically for the purpose of bone reconstruction.
疾病和损伤会导致显著的骨质流失，从而增加医疗费用、降低工作效率并使生活质量下降。由于供体来源有限，骨组织工程（BTE）作为自体和异体移植的替代方法正受到关注。生物材料是骨再生的一种有前景的策略，其设计应考虑骨组织工程中的三个关键过程：成骨、骨传导和骨诱导。某些胆汁酸（BAs）具有显著的抗氧化、抗炎和免疫抑制特性，并能有效促进骨和组织再生。此外，BA分子与其他生物材料的组合有助于克服局部骨再生有限相关的问题，并长时间维持特定的释放状态。因此，在本综述中，我们重点关注胆汁酸在不同条件下在骨愈合中的作用和机制，突出其独特性质以及在凝胶制备、微囊化和纳米技术中的应用。这些进展为源自胆汁酸的生物材料的发展奠定了基础，特别是用于骨重建的目的。
